Publications

Sakis (Athanasios) Mantalaris
List of Publications

1. Subcellular spatially resolved gene neighborhood networks in single cells. Z Fang, AJ Ford, T Hu, N Zhang, A Mantalaris, AF Coskun. Cell Reports Methods 3 (5), 2023.
2. A 3D bioprinted in vitro model of neuroblastoma recapitulates dynamic tumor‐endothelial cell interactions contributing to solid tumor aggressive behavior. L Ning, J Shim, ML Tomov, R Liu, R Mehta, A Mingee, B Hwang, L Jin, ... Advanced Science 9 (23), 2200244, 2022.
3. A spatiotemporal microenvironment model to improve design of a three-dimensional bioreactor for red cell production. MC Allenby, N Okutsu, K Brailey, J Guasch, Q Zhang, N Panoskaltsis, ... Tissue Engineering Part A 28 (1-2), 38-53, 2022.
4. Immune reconstitution and clinical recovery following anti-CD28 antibody (TGN1412)-induced cytokine storm. N Panoskaltsis, NE McCarthy, AJ Stagg, CJ Mummery, M Husni, N Arebi, ... Cancer Immunology, Immunotherapy 70, 1127-1142, 2021.
5. Patient‐Specific 3D Bioprinted Models of Developing Human Heart., AD Cetnar, ML Tomov, L Ning, B Jing, AS Theus, A Kumar, AN Wijntjes, ...Advanced healthcare materials 10 (15), 2001169, 2021., Mandates: US National Institutes of Health.
6. A 3D Bioprinted in vitro model of pulmonary artery atresia to evaluate endothelial cell response to microenvironment. ML Tomov, L Perez, L Ning, H Chen, B Jing, A Mingee, S Ibrahim, ...Advanced healthcare materials 10 (20), 2100968, 2021., Mandates: US National Institutes of Health.
7. Increased PIP3 activity blocks nanoparticle mRNA delivery. K Paunovska, A Da Silva Sanchez, MT Foster, D Loughrey, EL Blanchard, ... Science advances 6 (30), eaba5672, 2020., Mandates: US National Science Foundation, US National Institutes of Health.
8. Argyro Tsipa, Jake Alan Pitt, Julio R Banga, Athanasios Mantalaris. 2020. A dual‑parameter identification approach for data‑based predictive modeling of hybrid gene regulatory network‑growth kinetics in Pseudomonas putida mt‑2, Bioprocess and biosystems engineering, doi.org/10.1007/s00449-020-02360-2.
9. Panagiotis Karakostas, Nicki Panoskaltsis, Athanasios Mantalaris, Michael C Georgiadis. 2020. Optimization of CAR T-cell therapies Supply Chains, Computers & Chemical Engineering, 106913.
10. Gilad Doron, Michail E Klontzas, Athanasios Mantalaris, Robert E Guldberg, Johnna S. 2020. Multiomics characterization of mesenchymal stromal cells cultured in monolayer and as aggregates, Biotech & Bioeng, 117(6):1761-1778.
11. Kalina Paunovska, Alejandro Da Silva Sanchez, Matthew T Foster, David Loughrey, Emmeline L Blanchard, Fatima Z Islam, Zubao Gan, Athanasios Mantalaris, Philip J Santangelo, James E Dahlman. 2020. Increased PIP3 activity blocks nanoparticle mRNA delivery, Science Advances, 6(30): eaba5672.
12. Fotios Papadogiannis, Aristea Batsali, Michail E Klontzas, Maria Karabela, Anthie Georgopoulou, Athanasios Mantalaris, Nikolaos E Zafeiropoulos, Maria Chatzinikolaidou, Charalampos Pontikoglou. 2020. Osteogenic differentiation of bone marrow mesenchymal stem cells on chitosan/gelatinscaffolds: gene expression profile and mechanical analysis, Biomedical Materials, 15(6):064101.
13. Nicki Panoskaltsis, Neil E McCarthy, Andrew J Stagg, Catherine J Mummery, Mariwan Husni, Naila Arebi, David Greenstein, Claire L Price, Hafid O Al-Hassi, Michalis Koutinas, Athanasios Mantalaris, Stella C Knight. 2020. Immune reconstitution and clinical recovery following anti-CD28 antibody (TGN1412)-induced cytokine storm, Cancer Immunology, Immunotherapy, doi.org/10.1007/s00262-020-02725-2.
14. Alexander D Cetnar, Martin L Tomov, Liqun Ning, Bowen Jing, Andrea S Theus, Akaash Kumar, Amanda N Wijntjes, Sai Raviteja Bhamidipati, Katherine Pham Do, Athanasios Mantalaris, John N Oshinski, Reza Avazmohammadi, Brooks D Lindsey, Holly D Bauser‐Heaton, Vahid Serpooshan. 2020. Patient‐Specific 3D Bioprinted Models of Developing Human Heart, Advanceed Healthcare Materials, 2001169.
15. Győrgy, R., Klontzas, M.E., Kostoglou, M., Panoskaltsis, N., Mantalaris, A., and Georgiadis, M.C. 2019. Capturing Mesenchymal Stem Cell Heterogeneity during Osteogenic Differentiation: An Experimental–Modeling Approach, Ind & Eng Chem Res, 58(31):13900-13909.
16. Novosel, E., Borchers, K., Kluger, P.J., Mantalaris, A., Matheis, G., Pistolesi, M., Schneider, J., Wenz, A., and Lelkes, P.I. 2019. New approaches to respiratory assist: bioengineering an ambulatory, miniaturized bioartificial lung, ASAIO
17. Klontzas, M.E., Reakasame, S., Silva, R., Morais, J.C.F., Vernardis, S., MacFarlane, R.J., Heliotis, M., Tsiridis, E., Panoskaltsis, N., Boccaccini, A.R., and Mantalaris, A. 2019. Oxidized alginate hydrogels with the GHK peptide enhance cord blood mesenchymal stem cell osteogenesis: A paradigm for metabolomics-based evaluation of biomaterial design, Acta Biomaterilia, 88:224-240.
18. Devito, L., Klontzas, M.E., Cvoro, A., Galleu, A., Simon, M., Hobbs, C., Dazzi, F., Mantalaris, A., Khalaf, Y., and Ilic, D. 2019. Comparison of human isogeneic Wharton’s jelly MSCs and iPSC-derived MSCs reveals differentiation-dependent metabolic responses to IFNG stimulation. Cell Deat & Disease, 10(4):277-290.
19. Tahlawi, A., Klontzas, M.E., Allenby, M.C., Morais, J.C.F., Panoskaltsis, N., and Mantalaris, A. 2019. RGD‐functionalized polyurethane scaffolds promote umbilical cord blood mesenchymal stem cell expansion and osteogenic differentiation, JTERM, 13(2):232-243.
20. Grilo, A.L. and Mantalaris, A. 2019. A Predictive Mathematical Model of Cell Cycle, Metabolism, and Apoptosis of Monoclonal Antibody‐Producing GS–NS0 Cells. Biotech J.
21. Allenby, M.C., Panoskaltsis, N., Tahlawi, A., Brito Dos Santos, S., and Mantalaris, A. 2019. Dynamic human erythropoiesis in a three-dimensional perfusion bone marrow biomimicry. Biomaterials, 188:24-37.
22. Grilo, A.L. and Mantalaris, A. 2019. Apoptosis: A mammalian cell bioprocessing perspective. Biotech Adv, 37(3):459-475.
23. Grilo, A.L. and Mantalaris, A. 2019. The increasingly human and profitable monoclonal antibody market. Trends in Biotech, 37(1):9-16.
24. Totti, S., Allenby, M. C., Dos Santos, S. B., Mantalaris, A., Velliou, E. G. 2018. A 3D bioinspired highly porous polymeric scaffolding system for: In vitro simulation of pancreatic ductal adenocarcinoma. RSC Advances, 8:20928-20940.
25. Tsipa, A., Koutinas, M., Usaku, C., Mantalaris, A. 2018. Optimal bioprocess design through a gene regulatory network – Growth kinetic hybrid model: Towards replacing Monod kinetics. Metabolic Eng, 48: 129-137.
26. Quiroga-Campano, A.L., Panoskaltsis, N., Mantalaris, A. 2018. Energy-based culture medium design for biomanufacturing optimization: A case study in monoclonal antibody production by GS-NS0 cells, Metabolic Eng, 47:21-30.
27. Buldum, G., Bismarck, A., Mantalaris, A. 2018. Recombinant biosynthesis of bacterial cellulose in genetically modified Escherichia coli, Bioproc Biosys Eng, 41(2):265-279.
28. Győrgy, R., Klontzas, M.E., Kostoglou, M., Panoskaltsis, N., Georgiadis, M.C., Mantalaris, A. 2017. An Integrated Experimental-Modelling Approach of Mesenchymal Stem Cell Bioprocess towards Osteogenic Differentiation, IFAC-PapersOnLine, 50(1):9877-9882.
29. Kappatou, C.D., Mhamdi, A., Campano, A.Q., Mantalaris, A., Mitsos, A. 2017. Dynamic Optimization of the Production of Monoclonal Antibodies in Semi-batch Operation, CACE, 40:2161-2166.
30. Cha J.M., Mantalaris A., Jung S., Ji Y., Bang O.Y., Bae H. 2017. Mesoderm Lineage 3D Tissue Constructs Are Produced at Large-Scale in a 3D Stem Cell Bioprocess. Biotechnol J, 12(9):1600748.
31. Tsipa A., Koutinas M., Vernardis S.I., and Mantalaris A. 2017. The impact of succinate trace on pWW0 and ortho-cleavage pathway transcription in Pseudomonas putida mt-2 during toluene biodegradation. Bioresour Technol, 234:397-405.
32. Klontzas M.E., Vernardis S.I., Heliotis M., Tsiridis E., and Mantalaris A. 2017. Metabolomics Analysis of the Osteogenic Differentiation of Umbilical Cord Blood Mesenchymal Stem Cells Reveals Differential Sensitivity to Osteogenic Agents. Stem Cells Dev, 26(10):723-733.
33. Kang Y., Georgiou A.I., MacFarlane R.J., Klontzas M.E., Heliotis M., Tsiridis E., and Mantalaris A. 2017. Fibronectin stimulates the osteogenic differentiation of murine embryonic stem cells. J Tissue Eng Regen Med, 11(7):1929-1940.
34. Papathanasiou M.M, Quiroga-Campano A.L, Steinebach F., Elviro M., Mantalaris A., and Pistikopoulos E.N. 2017. Advanced model-based control strategies for the intensification of upstream and downstream processing in mAb production. Biotechnol Prog, 33(4):966-988.
35. Papathanasiou, M.M.,Steinebach, F., Mueller-Spaeth, T., Morbidelli, M., Mantalaris, A., and E. N. Pistikopoulos. 2017. Intelligent, model-based control towards the intensification of downstream processes. CACE, 105:173-184.
36. Vernardis, S.I., Terzoudis, K. Panoskaltsis, N., and A. Mantalaris. 2017. Human embryonic and induced pluripotent stem cells maintain phenotype but alter their metabolism after exposure to ROCK inhibitor. Scientific Reports, 7: article 42138.
37. Totti, S., Vernardis, S.I., Meira, L., Pérez-Mancera, P.A., Costello, E., Greenhalf, W., Palmer, D., Neoptolemos, J., Mantalaris, A., and Velliou, E.G. 2017. Designing a bio-inspired biomimetic in vitro system for the optimization of ex vivo studies of pancreatic cancer. Drug Discov Today, 22(4):690-701.
38. Allenby, M.C., Misener, R., Panoskaltsis, N., Mantalaris, A., 2017. A quantitative three-dimensional (3D) image analysis tool for maximal acquisition of spatial heterogeneity data. Tissue Eng Part C, 23(2):108-117.
39. Savvopoulos, S., Misener, R., Panoskaltsis, N., Pistikopoulos, E.N., Mantalaris, A., 2016. A Personalized Framework for Dynamic Modeling of Disease Trajectories in Chronic Lymphocytic Leukemia, IEEE Transactions on Biomedical Engineering, 63(11):2396-24-4.
40. Campano, A.Q., Papathanasiou, M.M., Pistikopoulos, E.N., Mantalaris, A., 2016. A Predictive Model for Energy Metabolism and ATP Balance in Mammalian Cells: Towards the Energy-Based Optimization of mAb Production, CACE, 38:1581-1586.
41. Zubairi, S.I. , Mantalaris, A., Bismarck, A., Aizad, S. Polyhydroxyalkanoates (PHAs) for tissue engineering applications: Biotransformation of palm oil mill effluent (POME) to value-added polymers. 2016. Jurnal Teknologi, 78(1):13-29.
42. Papathanasiou, M.M., Sun, M., Oberdieck, R., Mantalaris, A., Pistikopoulos, E.N. A centralized/decentralized control approach for periodic systems with application to chromatographic separation processes. 2016. IFAC-PapersOnLine, 49(7):159-164.
43. Reissis, D., Tang, Q.O., Cooper, N.C., Carasco, C.F., Gamie, Z., Mantalaris, A., Tsiridis, E. Current clinical evidence for the use of mesenchymal stem cells in articular cartilage repair. 2016. Expert Opinion on Biological Therapy, 16(4):535-557.
44. Klontzas, M.E., Kenanidis, E.I., MacFarlane, R.J., Michail, T., Potoupnis, M.E., Heliotis, M., Mantalaris, A., Tsiridis, E. Investigational drugs for fracture healing: Preclinical & clinical data. 2016. Expert Opinion on Investigational Drugs, 25(5):585-596.
45. Tsipa, A., Koutinas, M., Pistikopoulos, E.N., Mantalaris, A. Transcriptional kinetics of the cross-talk between the ortho-cleavage and TOL pathways of toluene biodegradation in Pseudomonas putida mt-2. 2016. Journal of Biotechnology, 228:112-123.
46. Papathanasiou, M.M., Avraamidou, S., Oberdieck, R., Mantalaris, A., Steinebach, F., Morbidelli, M., Mueller-Spaeth, T., Pistikopoulos, E.N. 2016. Advanced control strategies for the multicolumn countercurrent solvent gradient purification process. AIChE Journal, 7:2341-2357.
47. Severn, C.E., Macedi, H., Eagle, M.J., Rooney, P., Mantalaris, A., Toye, A.M. 2016. Polyurethane scaffolds seeded with CD34 + cells maintain early stem cells whilst also facilitating prolonged egress of haematopoietic progenitors. Scientific Reports, 6:32149.
48. Kostoglou, M. , Fuentes-Garí, M., García-Münzer, D., Georgiadis, M.C., Panoskaltsis, N., Pistikopoulos, E.N., Mantalaris, A. A comprehensive mathematical analysis of a novel multistage population balance model for cell proliferation. 2016. Computers and Chemical Engineering, 91:157-166.
49. Zavitsanou, S., Mantalaris, A., Georgiadis, M.C., Pistikopoulos, E.N.In silico closed-loop control validation studies for optimal insulin delivery in type 1 diabetes. 2015. IEEE Transactions on Biomedical Engineering, 62(10):2369-2378.
50. Fuentes-Garí, M., Misener, R., Georgiadis, M.C., Kostoglou, M., Panoskaltsis, N., Mantalaris, A., Pistikopoulos, E.N. 2015. Selecting a Differential Equation Cell Cycle Model for Simulating Leukemia Treatment . Ind Eng Chem Res, 54(36): 8847-8859.
51. Zubairi, S. I., Bismarck, A., & Mantalaris, A. 2015. The effect of surface heterogeneity on wettability of porous three dimensional (3-D) scaffolds of poly(3-hydroxybutyric acid) (PHB) and poly(3-hydroxybutyric-co-3-hydroxyvaleric acid) (PHBV). Jurnal Teknologi, 75(1): 305-312.
52. Klontzas, M. E., Kenanidis, E. I., Heliotis, M., Tsiridis, E., & Mantalaris, A. 2015. Bone and cartilage regeneration with the use of umbilical cord mesenchymal stem cells. Expert Opinion on Biological Therapy: 1-12.
53. García Münzer, D. G., Kostoglou, M., Georgiadis, M. C., Pistikopoulos, E. N., & Mantalaris, A. (2015). Cyclin and DNA Distributed Cell Cycle Model for GS-NS0 Cells. PLoS Computational Biology, 11(2).
54. García Münzer, D. G., Ivarsson, M., Usaku, C., Habicher, T., Soos, M., Morbidelli, M., Pistikopoulos, E. N., & Mantalaris, A. 2015. An unstructured model of metabolic and temperature dependent cell cycle arrest in hybridoma batch and fed-batch cultures. Biochemical Engineering Journal, 93: 260-273.
55. Fuentes-Garí, M., Velliou, E., Misener, R., Pefani, E., Rende, M., Panoskaltsis, N., Mantalaris, A., & Pistikopoulos, E. N. 2015b. A systematic framework for the design, simulation and optimization of personalized healthcare: Making and healing blood. Computers & Chemical Engineering, 81: 80-93.
56. Fuentes-Garí, M., Misener, R., García-Munzer, D., Velliou, E., Georgiadis, M. C., Kostoglou, M., Pistikopoulos, E. N., Panoskaltsis, N., & Mantalaris, A. 2015. A mathematical model of subpopulation kinetics for the deconvolution of leukaemia heterogeneity. Journal of the Royal Society Interface, 12(108).
57. Velliou, E., Dos Santos, S., Papathanasiou, M., Fuentes-Gari, M., Misener, R., Panoskaltsis, N., Pistikopoulos, E., & Mantalaris, A. 2015. Towards unravelling the kinetics of an acute myeloid leukaemia model system under oxidative and starvation stress: a comparison between two- and three-dimensional cultures. Bioprocess and Biosystems Engineering, 38(8): 1589-1600.
58. Yeo, D. C., Wiraja, C., Mantalaris, A., & Xu, C. J. 2014. Nanosensors for Regenerative Medicine. Journal of Biomedical Nanotechnology, 10(10): 2722-2746.
59. Velliou, E., Dos Santos, S. B., Gari, M. F., Misener, R., Panoskaltsis, N., Pistikopoulos, E., & Mantalaris, A. 2014. Evolution of an AML model system under oxidative & starvation stress: a comparison between two and three dimensional cultures. Journal of Tissue Engineering and Regenerative Medicine, 8: 383-383.
60. Teo, A., Mantalaris, A., & Lim, M. 2014. Influence of culture pH on proliferation and cardiac differentiation of murine embryonic stem cells. Biochemical Engineering Journal, 90: 8-15.
61. Rende, M., Panoskaltsis, N., Morilla, R., & Mantalaris, A. 2014. Novel successful cytokine-free culture of acute leukemic cells in a perfused hollow-fiber bioreactor. Journal of Tissue Engineering and Regenerative Medicine, 8: 48-48.
62. Pefani, E., Panoskaltsis, N., Mantalaris, A., Georgiadis, M. C., & Pistikopoulos, E. N. 2014. Chemotherapy drug scheduling for the induction treatment of patients with acute myeloid leukemia. IEEE Transactions on Biomedical Engineering, 61(7): 2049-2056.
63. Misener, R., Fuentes Garí, M., Rende, M., Velliou, E., Panoskaltsis, N., Pistikopoulos, E. N., & Mantalaris, A. 2014. Global superstructure optimisation of red blood cell production in a parallelised hollow fibre bioreactor. Computers and Chemical Engineering, 71: 532-553.
64. Marzinek, J. K., Bond, P. J., Lian, G., Zhao, Y., Han, L., Noro, M. G., Pistikopoulos, E. N., & Mantalaris, A. 2014. Free energy predictions of ligand binding to an α-helix using steered molecular dynamics and umbrella sampling simulations. Journal of Chemical Information and Modeling, 54(7): 2093-2104.
65. Lu, X., Vernardis, S. I., Lelkes, P. I., Polak, P. M., & Mantalaris, A. 2014. Characterization and Functional Analysis of Endothelial Cells Derived from Human Embryonic Stem Cells. Tissue Engineering Part A, 20: S84-S85.
66. Lee, K. Y., Buldum, G., Mantalaris, A., & Bismarck, A. 2014. More Than Meets the Eye in Bacterial Cellulose: Biosynthesis, Bioprocessing, and Applications in Advanced Fiber Composites. Macromolecular Bioscience, 14(1): 10-32.
67. Krieger, A., Panoskaltsis, N., Mantalaris, A., Georgiadis, M. C., & Pistikopoulos, E. N. 2014. Modeling and analysis of individualized pharmacokinetics and pharmacodynamics for volatile anesthesia. IEEE Transactions on Biomedical Engineering, 61(1): 25-34.
68. Kiparissides, A., Georgakis, C., Mantalaris, A., & Pistikopoulos, E. N. 2014. Design of in silico experiments as a tool for nonlinear sensitivity analysis of knowledge-driven models. Industrial and Engineering Chemistry Research, 53(18): 7517-7525.
69. Gamie, Z., MacFarlane, R. J., Tomkinson, A., Moniakis, A., Tran, G. T., Gamie, Y., Mantalaris, A., & Tsiridis, E. 2014. Skeletal tissue engineering using mesenchymal or embryonic stem cells: clinical and experimental data. Expert Opinion on Biological Therapy, 14(11): 1611-1639.
70. Fauzi, I., Panoskaltsis, N., & Mantalaris, A. 2014. Early exposure of murine embryonic stem cells to hematopoietic cytokines differentially directs definitive erythropoiesis and cardiomyogenesis in alginate hydrogel three-dimensional cultures. Stem Cells and Development, 23(22): 2720-2729.
71. Rende, M., Mantalaris, A., Morilla, R., Aqel, N., & Panoskaltsis, N. 2013. Biology Of Mixed Phenotype Acute Leukemia In Successful Long-Term Cytokine-Free Three-Dimensional (3D) Static and Perfused 3D Hollow-Fibre Bioreactor Culture. Blood, 122(21).
72. Phan, T. H. H., Saraf, P., Kiparissides, A., Mantalaris, A., Song, H., & Lim, M. 2013. An in silico erythropoiesis model rationalizing synergism between stem cell factor and erythropoietin. Bioprocess and Biosystems Engineering, 36(11): 1689-1702.
73. Pefani, E., Panoskaltsis, N., Mantalaris, A., Georgiadis, M. C., & Pistikopoulos, E. N. 2013. Design of optimal patient-specific chemotherapy protocols for the treatment of acute myeloid leukemia (AML). Computers & Chemical Engineering, 57: 187-195.
74. Panoskaltsis, N., Pefani, E., Mantalaris, A., Georgiadis, M., & Pistikopoulos, E. 2013. Optimized Patient- and Leukemia-Specific Chemotherapy Protocols For The Treatment Of Acute Myeloid Leukemia. Blood, 122(21).
75. Munzer, D. G. G., Kostoglou, M., Georgiadis, M. C., Pistikopoulos, E. N., & Mantalaris, A. 2013. Developing a cyclin blueprint as a tool for mapping the cell cycle in GS-NSO. Biochemical Engineering Journal, 81: 97-107.
76. Marzinek, J. K., Lian, G. P., Marzinek, J. K., Mantalaris, A., Pistikopoulos, E. N., Zhao, Y. Y., Han, L. J., Chen, L. J., Bond, P. J., & Noro, M. G. 2013. Molecular and Thermodynamic Basis for EGCG-Keratin Interaction-Part I: Molecular Dynamics Simulations. Aiche Journal, 59(12): 4816-4823.
77. Davies, P. S. E., Graham, S. M., MacFarlane, R. J., Leonidou, A., Mantalaris, A., & Tsiridis, E. 2013. Disease-modifying osteoarthritis drugs: in vitro and in vivo data on the development of DMOADs under investigation. Expert Opinion on Investigational Drugs, 22(4): 423-441.
78. Mortera-Blanco, T. M. Rende, H. Macedo, S. Farah, A. Bismarck, A. Mantalaris, and N. Panoskaltsis (2012). Ex vivo mimicry of normal and abnormal human hematopoiesis, J Vis Exp 10(62):3654.
79. Tang, Q.O., C.F. Carasco, Z. Gamie, N. Korres, A. Mantalaris, and E. Tsiridis (2012). Preclinical and clinical data for the use of mesenchymal stem cells in articular cartilage tissue engineering, Expert Opin Biol Ther 12(10):1361-82.
80. Tsapakis E.M., Z. Gamie, G.T. Tran, S. Asdshead, A. Lampard, A. Mantalaris, and E. Tsiridis (2012). The adverse skeletal effects of selective serotonin reuptake inhibitors, Eur Psych 27:156-169.
81. Fauzi, I., N. Panoskaltsis, and A. Mantalaris (2012). Enhanced Hematopoietic Differentiation Toward Erythrocytes from Murine Embryonic Stem Cells with HepG2-Conditioned Medium, Stem Cells Dev, 21(17):3152-3161.
82. Gamie, Z., G.T. Tran, G. Vyzas, N. Korres, M. Heliotis, A. Mantalaris, and E. Tsiridis (2012). Stem cells combined with bone graft substitutes in skeletal tissue engineering, Exp Opin Biol Ther 12:713-729.
83. Ma, C.Y.J., N. Panoskaltsis, R. Kumar, X.Y. Xu, and A. Mantalaris (2012). Simulation of ex vivo bone marrow culture: Application to chronic myeloid leukaemia growth model, Biochem Eng J 61:66-77.
84. Lim, M., C. Shunjie, N. Panoskaltsis, and A. Mantalaris (2012). Systematic experimental design for bioprocess characterization: Elucidating transient effects of multi-cytokine contributions on erythroid differentiation, Biotech Bioproc Eng 17(1):218-226.
85. Consolo, F., Bariani, C., Mantalaris, A., Montevecchi, F., Redaelli, A., and Morbiducci, U. (2012). Computational modeling for the optimization of a cardiogenic 3D bioprocess of encapsulated embryonic stem cells, BIOMECHANICS AND MODELING IN MECHANOBIOLOGY 11(1-2): 261-277.
86. Kallala, R., Graham, S.M., Nikkhah, D., Kyrkos, M., Heliotis, M., Mantalaris, A., and Tsiridis, E. (2012). In vitro and in vivo effects of antibiotics on bone cell metabolism and fracture healing, Exp Opin Drug Safety 11(1):15-32.
87. Ismail S., A. Samadikuchaksaraei, A. Bishop, J.M. Polak, and A. Mantalaris (2012). Development of a novel three-dimensional, automatable and integrated bioprocess for the differentiation of embryonic stem cells into pulmonary alveolar cells in a rotating vessel bioreactor system, Tissue Eng Part C Methods 18(4):263-272.
88. Ho, Y., A. Kiparissides, E.N. Pistikopoulos, and A. Mantalaris (2012). Computational approach for understanding and improving GS-NS0 antibody production under hyperosmotic conditions, Journal of Bioscience and Bioengineering 113(1):88-98.
89. Graham, S.M., D. Howgate, W. Anderson, C. Howes, M. Heliotis, A. Mantalaris, E. Tsiridis, E. Tsapakis (2011). Risk of osteoporosis and fracture incidence in patients on antipsychotic medication, Expert Opinion on Drug Safety 10(4):575-602.
90. Mortera-Blanco, T., A. Mantalaris, A. Bismarck, N. Aqel, and N. Panoskaltsis (2011). Long-term cytokine-free expansion of cord blood mononuclear cells in three-dimensional scaffolds, Biomaterials 32(35):9263-70.
91. Ripamonti, U., E. Tsiridis, C. Ferretti, C.J. Kerawala, A. Mantalaris, and M. Heliotis (2011). Perspectives in regenerative medicine and tissue engineering of bone, British Journal of Oral & Maxillofacial Surgery 49(7):507-509.
92. Koutinas, M., A. Kiparissides, M-C. Lam, R. Silva-Rocha, M. Godinho, V. de Lorenzo, V.A.P. Martins dos Santos, E.N. Pistikopoulos, and A. Mantalaris (2011). Linking genes to microbial growth kinetics – An integrated biochemical systems engineering approach, Metabolic Engineering 13:401-413.
93. Kiparissides, A., M. Koutinas, C. Kontoravdi, A. Mantalaris, E.N. Pistikopoulos (2011). “Closing the loop in biological systems modelling – From the in silico to the in vitro, Automatica 47(6): 1147-1155.
94. Lim, M., N. Panoskaltsis, H. Ye, and A. Mantalaris (2011). Optimization of in vitro erythropoiesis from CD34+ cord blood cells using design of experiments (DOE), Biochemical Engineering Journal 55(3): 154-161.
95. Koutinas, M., A. Kiparissides, M-C. Lam, R. Silva-Rocha, M. Godinho, V. de Lorenzo, V.A.P. Martins dos Santos, E.N. Pistikopoulos, and A. Mantalaris (2011). Improving the prediction of Pseudomonas putida mt-2 growth kinetics with the use of a gene expression regulation model of the TOL plasmid, Biochemical Engineering Journal 55(2): 108-118.
96. Mantalaris, A. (2011). Bioprocess Systems Engineering: bridging the “scales” between “molecules, cells & processes”, Microbial Biotechnology 4(2):212-124.
97. Kuzin, I. HL. Sun, S. Moshkani, CY. Feng, A. Mantalaris, J.H.D. Wu, and A. Bottaro (2011). Long-Term Immunologically Competent Human Peripheral Lymphoid Tissue Cultures in a 3D Bioreactor, Biotechnology & Bioengineering 108(6): 1430-1440.
98. Kiparissides, A., M. Koutinas, T. Moss, J. Newman, E.N. Pistikopoulos, and A. Mantalaris (2011). Modelling the Delta1/Notch1 Pathway: In Search of the Mediator(s) of Neural Stem cell Differentiation, Plos One 6(2):e14668.
99. Quero, F., M. Nogi, K-Y. Lee, G.V. Poel, A. Bismarck, A. Mantalaris, H. Yano, S.J. Eichorn (2011). Cross-Linked Bacterial Cellulose Networks Using Glyoxalization, ACS Applied Materials & Interfaces 3(2):490-499.
100. Seong, J.M., B-C. Kim, J-H. Park, I.K. Kwon, A. Mantalaris, and Y.S. Hwang (2010). Stem cells in bone tissue engineering, Biomedical Materials 5(6):062001.
101. Ferretti, C., U. Ripamonti, E. Tsiridis, C.J. Kerawala, A. Mantalaris, and M. Heliotis (2010). Osteoinduction: translating preclinical promise into clinical reality, British Journal of Oral and Maxillofacial Surgery 48(7):536-539.
102. Lim, Y., A. Mantalaris, M.G. Yap, and D.C. Wong (2010). Simultaneous targeting of requiem & alg-2 in chinese hamster ovary cells for improved recombinant protein production 46(3):301-7.
103. Blaker J.J., K-Y. Lee, A. Mantalaris, and A. Bismarck (2010). Ice microsphere templating to produce highly porous nanocomposite PLA matrix scaffolds with pores selectively lined by bacterial cellulose nano-whiskers, Composites Science and Technology 70(13):1879-1888.
104. Yue. X., E.M. Drakakis, A. Mantalaris, and T. Cass (2010). Generation of spatio-temporal concentration profiles for cell culture systems: a case study in ammonia, Measurement 43(9):1207-1216.
105. Kontoravdi, C., E.N. Pistikopoulos, and A. Mantalaris (2010). Systematic development of predictive mathematical models for animal cell cultures, Computers & Chemical Engineering 34(8):1191-1198.
106. Koutinas, M., M.C. Lam, A. Kiparissides, R. Silva-Rocha, M. Godinho, A.G. Livingston, E.N. Pistikopoulos, V. de Lorenzo, V.A.P.Martins dos Santos, and A. Mantalaris (2010). The regulatory logic of m-xylene biodegradation by Pseudomonas putida mt-2 exposed by dynamic modelling of the principal node Ps/Pr of the TOL plasmid, Environmental Microbiology 12(6):1705-1718.
107. Pagkalos, J., J.M. Cha, Y. Kang, M. Heliotis, E. Tsiridis, and A. Mantalaris (2010). Simvastatin induces osteogenic differentiation of murine embryonic stem cells, Journal of Bone & Mineral Research 25(11):2470-2478.
108. Graham, S.M., A. Leonidou, N. Aslam-Pervez, A. Hamza, P. Panteliadis, M. Heliotis, A. Mantalaris, E. Tsiridis. 2010. Biological therapy of bone defects: the immunology of bone allo-transplantation, Expert Opin Biol Ther 10(6):885-901.
109. Mortera Blanco, T., A. Mantalaris, A. Bismarck, and N. Panoskaltsis (2010). Development of a three-dimensional biomimicry of human acute myeloid leukaemia ex vivo, Biomaterials 31(8):2243-2251.
110. Lim, Y., V.X.F. Seah, A. Mantalaris. M.G.S. Yap, D.C.F. Wong. 2010. Elucidating the role of requiem in the growth and death of Chinese Hamster Ovary (CHO) Cells, Apoptosis 15(4):450-462.
111. Graham, S., Leonidou, A., Lester, M., Heliotis, M., Mantalaris, A., Tsiridis, E. (2009). Investigating the role of PDGF as a potential drug therapy in bone formation and fracture healing, Expert OpinInvestig Drugs 18(11):1633-54.
112. Howgate, D.J., Gamie, Z., Panteliadis, P., Bhalla, A., Mantalaris, A., Tsiridis, E. (2009). The potential adverse effects of aromatase inhibitors on wound healing: in vitro and in vivo evidence, Expert OpinDrug Saf 8(5):523-35.
113. Kiparissides, A., Kucherenko, S.S., Mantalaris, A., and Pistikopoulos, E.N. (2009). Global Sensitivity Analysis Challenges in Biological Systems Modeling, Industrial & Engineering Chemical Research 48(15):7168-7180.
114. Tran, G.T., J. Pagkalos, A.A. Narvani, M. Heliotis, Mantalaris, A., and E. Tsiridis (2009). Growth hormone:does it have a therapeutic role in fracture healing? Expert Opinion on Investigational Drugs 18(7):887-911.
115. Graham S., Z. Gamie, I. Polyzois, A.A. Narvani, K. Tzafetta, E. Tsiridis, M. Heliotis, A. Mantalaris, E. Tsiridis (2009). Prostglandin EP2 and EP4 receptor agonists in bone formation and bone healing: In vivo and in vitro evidence, Expert Opinion on Investigational Drugs 18(6):749-766.
116. Tang Q.O., K. Shakib, M. Heliotis, E. Tsiridis, A. Mantalaris, U. Ripamonti, and E. Tsiridis (2009). TGF-beta3: A potential biological therapy for enhancing chondrogenesis, Expert Opinion on Biological Therapy 9(6):689-701.
117. Heliotis, M., U. Ripamonti, C. Kerawala, A. Mantalaris, and E. Tsiridis (2009). The basic science of bone induction, British Journal of Oral & Maxillofacial Surgery 47(7):511-514.
118. Placzek, M.R., I-M. Chung, H.M. Macedo, S. Ismail, T. Mortera Blanco, M. Lim, J.M. Cha, I. Fauzi, Y. Kang, D.C. Yeo, Y.J.C. Ma C, J.M. Polak, N. Panoskaltsis, and A. Mantalaris (2009). Stem Cell Bioprocessing: Fundamentals and Principles, Journal of the Royal Society Interface 6(32):209-232.
119. Hwang, Y.S., J. Cho, F. Tay, J.Y. Heng, R. Ho, S.G. Kazarian, D.R. Williams, A.R. Boccaccini, J.M. Polak, and A. Mantalaris (2009). The use of murine embryonic stem cells, alginate encapsulation, and rotary microgravity bioreactor in bone tissue engineering, Biomaterials 30(4):499-507.
120. Kang, Y., T. Techanukul, A. Mantalaris, and J.M. Nagy (2009). Comparison of Three Commercially Available DIGE Analysis Software Packages: Minimal User Intervention in Gel-Based Proteomics, Journal of Proteome Research 8(2):1077-84.
121. Zhang, J., M. Wang, J.M. Cha, and A. Mantalaris (2009). The incorporation of 70s bioactive glass to the osteogenic differentiation of murine embryonic stem cells in 3D bioreactors, Journal of Tissue Engineering & Regenerative Medicine 3(1):63-71.
122. Radomska, A., S. Singhal, H. Ye, M. Lim, A. Mantalaris, X.C. Yue, E.M. Drakakis, C. Toumazou, and A.E.G. Cass (2008). Biocompatible ion selective electrode for monitoring metabolic activity during the growth and cultivation of human cells, Biosensors & Biolectronics 24(3):435-441.
123. Juntaro, J., M. Pommet, G. Kalinka, A. Mantalaris, M.S.P. Shaffer, and A. Bismarck (2008). Creating hierarchical structures in renewable composites by attaching bacterial cellulose onto sisal fibers, Advanced Materials 20(16):3122-3126.
124. Kang, Y., A.G.E. Cass, A. Mantalaris, and J.M. Nagy (2008). CCD Imaging 2D-DIGE gels of secreted proteins from cell conditioned mesia is helping identify possible factors to control ES cell differentiation, Genetic Engineering & Biotechnology News 28(15):60-61.
125. Siti-Ismail, N., A.E. Bishop, J.M. Polak, and A. Mantalaris (2008). Encapsulation of human embryonic stem cells supports prolonged feeder-free maintenance Biomaterials 29(29):3946-3952.
126. Kang, Y., J.M. Nagy, J.M. Polak, and A. Mantalaris (2008). Proteomic characterisation of the conditioned media produced by the visceral endoderm-like cell lines HepG2 and End2: Towards a defined medium for the osteogenic/chondrogenic differentiation of embryonic stem cells, Stem Cells & Development 18(1):77-92.
127. Hwang, Y-S., J.M. Polak, and A. Mantalaris (2008). In Vitro Direct Chondrogenesis of Murine Embryonic Stem Cells by Bypassing Embryoid Body Formation, Stem Cells & Development 17(5):971-978.
128. Hwang, Y-S., J.M. Polak, and A. Mantalaris (2008). In Vitro Direct Osteogenesis of Murine Embryonic Stem Cells without Embryoid Body Formation, Stem Cells & Development 17(5):963-970.
129. Safinia, L., K. Wilson, A. Mantalaris, and A. Bismarck (2008). Through Thickness Plasma Modification of Biodegradable and non-Biodegradable Porous Polymer Constructs, Journal of Biomedical Materials Research: Part A 87A(3):632-642.
130. Yue,X., E.M.Drakakis, M.Lim, A.Radomska, H.Ye, A.Mantalaris, N.Panoskaltsis, A.E.G.Cass(2008). A Real-time, Multi-channel Monitoring System for Stem Cell Culture Process, IEEE Transactions on BioMedical Circuits & Systems 2: 66 – 77.
131. Lim, M., H. Ye, E.M. Drakakis, X. Yue, A.E.G. Cass, and A. Mantalaris (2008). Towards information-rich stem cell bioprocessing: generation of spatial and temporal profiles through the use of design of experiments to determine optimal number and location of sensors, Biochemical Engineering Journal 40(1):1-7.
132. Kumar, R., N. Panoskaltsis, F. Stepanek, and A. Mantalaris (2008). Coupled Oxygen-Carbon Dioxide Transport Model for the Human Bone Marrow, Food and Bioproducts Processing 86(C3):211-219.
133. Pommet, M., J. Juntaro, J.Y, Heng, A. Mantalaris, A.F. Lee, K. Wilson, G. Kalinka, M.S. Shaffer, and A. Bismarck (2008). Surface modification of natural fibers using bacteria: depositing bacterial cellulose onto natural fibers to create hierarchical fiber reinforced nanocomposites, Biomacromolecules 9(6): 1643-1651.
134. Chung, I-M., N.O. Enemchukwu, S.D. Khaja, N. Murthy, A. Mantalaris, A.J. Garcia (2008). Bioadhesive hydrogel microenvironments to modulate epithelial morphogenesis, Biomaterials 29(17):2637-2645.
135. Polak J.M. and A. Mantalaris (2008). Stem Cell Bioprocessing: An Important Milestone to Move Regenerative Medicine Research Into the Clinical Arena, Pediatric Research 63(5):461-6.
136. Baptista, I., N.Y. Zhou, E.A.C. Emanuelsson, L.G. Peeva, D.J. Leak, A. Mantalaris, A.G. Livingston (2008). Evidence of Species Succession during Chlorobenzene Biodegradation, Biotechnology & Bioengineering 99(1):69-74. – spotlight in Biotech & Bioeng (Jan 2008)
137. Kontoravdi, C., D. Wong, C. Lam, Y.Y. Lee, M. Yap, E.N. Pistikopoulos, and A. Mantalaris (2007). Modelling Amino Acid Metabolism in Mammalian Cells - Towards the Development of a Model Library, Biotechnology Progress 23(6):1261-1269.
138. Hwang, Y-S., A.E. Bishop, J.M. Polak, and A. Mantalaris (2007). Enhanced In Vitro Chondrogenic Differentiation of Murine Embryonic Stem Cells, Biotechnology and Bioprocess Engineering 12(6):696-706.
139. Randle, W.L., J.M. Cha, Y-S. Hwang, A. Chan, S.G. Kazarian, J.M. Polak, and A. Mantalaris (2007). Integrated 3D expansion and osteogenic differentiation of murine embryonic stem cells, Tissue Engineering 13(12):2957-2970.
140. Lim, M., H. Ye, M. Plazcek, and A. Mantalaris (2007). Stem Cell Bioprocessing: Manufacturing Cells for Clinical Applications, Bioworld Europe S1:10-13.
141. Juntaro, J., M. Pommet, A. Mantalaris, M. Shaffer, and A, Bismarck (2007). Nanocellulose enhanced interfaces in truly green unidirectional fibre reinforced composites, Composite Interfaces 14(7-9):753-762.
142. Koutinas, M., I. Baptista, A. Meniconi, L.G. Peeva, A. Mantalaris, P.M. Castro, and A.G. Livingston (2007). The Use of an Oil-Absorber-Bioscrubber System During Biodegradation of Sequentially Alternating Loadings of 1,2-Dichloroethane and Fluorobenzene in a Waste Gas, Chemical Engineering Science 62(21):5989-6001.
143. Lim, M., H. Ye, N. Panoskaltsis, E.M. Drakakis, A. Yue, A.G.E. Cass, A. Radomska, and A. Mantalaris (2007). Intelligent Bioprocessing for Haematopoietic Cell Cultures using Monitoring and Design of Experiments, Biotechnology Advances 25(4):353-68.
144. Safinia L., K. Wilson, A. Mantalaris, and A Bismarck (2007). Atmospheric Plasma Treatment of Porous Polymer Constructs for Tissue Engineering Applications, Macromolecular Bioscience 7(3):315-327.
145. Hwang, Y-S., Y. Kang and A. Mantalaris (2007). Directing Embryonic Stem Cell Differentiation into Osteogenic/Chondrogenic Lineage in vitro, Biotechnology and Bioprocess Engineering 12(1)15-21.
146. Kontoravdi, C., S.P. Asprey, E.N. Pistikopoulos and A. Mantalaris (2007). Development of a dynamic model of monoclonal antibody production and glycosylation for product quality monitoring, Computers in Chemical Engineering 31(5-6):392-400.
147. Ma, C.Y.J., R. Kumar, X. Y. Xu, and A. Mantalaris (2007). A combined fluid dynamics, mass transport and cell growth model for a three-dimensional perfused biorector for tissue engineering of haematopoietic cells, Biochemical Engineering Journal 35(1)1-11.
148. Baptista, I., L.G. Peeva, N. Zhou, D. Leak, A. Mantalaris, A.G. Livingston (2006). Stability study of strain Xanthobacter autothrophicus sp. GJ10 degrading 1,2-dichloroethane using molecular techniques Applied and Envrionmental Biotechnology 72(6):4411-4418.
149. Ho, Y., J. Varley and A. Mantalaris (2006). Development and analysis of a mathematical model for antibody producing GS-NS0 cells under normal and hyperosmotic culture conditions, Biotechnology Progress 22(6):1560-1569.
150. Sidoli, F.R., S.P. Asprey, and A. Mantalaris (2006). A coupled single cell-population-balance model for mammalian cell cultures, Industrial & Engineering Chemistry Research 45(16):5801-5811.
151. Safinia, L., A. Mantalaris and A. Bismarck (2006). A Non-Destructive Technique for the Characterisation of the Pore Size Distribution of Porous Media, Langmuir 22(7):3235-42.
152. Koutinas, M., J. Martin, L.G. Peeva, A. Mantalaris, A.G. Livingston (2006). Oil-Absorber-Bioscrubber System for Treatment of 1,2-Dichloroethane Waste-Gas Fluctuating Loads, Environmental Science & Technology 40(2):595-602.
153. Hwang, Y-S., W.L. Randle, R.C. Bielby, J.M. Polak, and A. Mantalaris (2006). Enhanced derivation of osteogenic cells from murine embryonic stem cells following treatment with HepG2 conditioned medium and modulation of the embryoid body formation period: application to skeletal tissue engineering, Tissue Engineering 12(6):1381-1392.
154. Emanuelsson, E.A.C., I.I.R. Baptista, A. Mantalaris, and A.G. Livingston (2005). Strain Stability in Biological Systems Treating Recalcitrant Organic Compounds, Biotechnology and Bioengineering 92(7):843-849. – spotlight in Biotech & Bioeng (Jan 2008)
155. Safinia, L., N. Datan, M. Höhse, A. Mantalaris and A. Bismarck (2005). Towards a methodology for the effective surface modification of porous polymer scaffolds, Biomaterials 26:7537-7547.
156. Panoskaltsis, N., A. Mantalaris, and J.H.David Wu (2005). Engineering a Mimicry of Bone Marrow Tissue Ex Vivo, Journal of Bioscience and Bioengineering 100(1):28-35.
157. Kontoravdi, C., S.P. Asprey, E.N. Pistikopoulos and A. Mantalaris (2005). Application of Global Sensitivity Analysis to Determine Goals for Design of Experiments – An Example Study on Antibody-producing Cell Cultures, Biotechnology Progress 21: 1128-1135.
158. Safinia, L., J.J. Blaker, V. Maquet, A.R. Boccaccini, A. Mantalaris, and A. Bismarck (2005). Characterisation of ‘wet’ polymer surfaces for tissue engineering applications: Are flat surfaces a suitable model for complex structures? E-Polymers no10.
159. Sidoli, F., A. Mantalaris, and S.P. Asprey (2005). Toward Global Parametric Estimability of a Large-Scale Kinetic Single-Cell Model for Mammalian Cell Cultures, Industrial & Engineering Chemistry Research 44:868-878.
160. Coward, S. M., C. Selden, A. Mantalaris, and H. J. F. Hodgson (2005). Proliferation Rates of HepG2 Cells Encapsulated in Alginate Are Increased in a Microgravity Environment Compared With Static Cultures, Artificial Organs 29(2):152-158.
161. Wu, M-H., G. Dimopoulos, A. Mantalaris, and J. Varley (2005). Osmotic effect on expression profile of GS-NS0 system, in Animal Cell Technology Meets Genomics, F. Godia and M. Fussenegger, Eds, Springer, p 3-13.
162. Kumar, R., F. Stepanek, and A. Mantalaris (2004). An oxygen transport model for the human bone marrow microcirculation, Food and Bioproducts Processing 82(C2):105-116.
163. Sidoli, F., A. Mantalaris, S.P. Asprey (2004). Modelling of mammalian cells and cell culture processes, Cytotechnology 44(1-2):27-46.
164. Wu, M-H., G. Dimopoulos, A. Mantalaris, and J. Varley (2004). The effect of hyperosmotic pressure on the antibody production and gene expression of GS-NS0 cell line, Biotechnology and Applied Biochemistry 40:41-46.
165. Mantalaris, A., P. Bourne, and J.H.D. Wu (2004). Production of Human Osteoclasts in a Three-Dimensional Bone Marrow Culture System, Biochemical Engineering Journal 15(2-3):189-196.
166. Omasa, T., Y-G. Chen, A. Mantalaris, and J.H.D. Wu (2002). Molecular cloning and sequencing of the human heme-regulated eukaryotic initiation factor-2 alpha (eIF-2alpha) kinase from bone marrow culture, DNA Sequence 13(3):133-137.
167. Mantalaris, A. (2001). Tissue Engineering: A passing fad or a viable field for chemical engineers? TCE 720:32-34.
168. Waugh, R., A. Mantalaris, R.G. Bauserman, W.C. Huang, and J.H.D. Wu (2001). Membrane instability in late stage erythropoiesis. Blood 97(6):1869-1875.
169. Omasa, T., Y-G. Chen, A. Mantalaris, and J.H.D. Wu (2001). A cDNA from human bone marrow encoding a protein exhibiting homology to the ATP11/PLM/MAT8 family of transmembrane proteins. Biochim. Biophys. Acta 1517(2):307-310.
170. Mantalaris, A., N. Panoskaltsis, Y. Sakai, P. Bourne, C Chang, E.M. Messing, and J.H.D. Wu (2001). Localization of androgen receptor expression in human bone marrow. Journal of Pathology 193(3):361-366.
171. Chen, Y-G., A. Mantalaris, P. Keng, and J.H.D. Wu (2000). Expression of mPer1 and mPer2 genes, two mammalian clock genes, in murine bone marrow Biochemical Biophysical Research Communications 276(2):724-728.
172. Mantalaris, A., P. Keng, P. Bourne, A.Y.C. Chang, and J.H.D. Wu (1998). Engineering a human bone marrow model: a case study on ex vivo erythropoiesis. Biotechnology Progress 14:126-133.
173. Mantalaris, A. and J.H.D. Wu (1995). Developing an ex vivo mimic of bone marrow: a three-dimensional bone marrow bioreactor. Bulletin of Intensive and Critical Care 2:12-15.
174. Wang, T.Y., A. Mantalaris, and J.H.D. Wu (1994). A novel three-dimensional long-term bone marrow bioreactor culture system. In: T. Kobayashi, Y. Kitagawa, and K. Okumura (editors), Animal Cell Technology: Basic & Applied Aspects, Vol. 6, pp115-120. Dordrecht: Kluwer Academic Publishers.
1. Three-Dimensional Human Bone Marrow Organoids for the Study and Application of Normal and Abnormal Hematoimmunopoiesisde., Janon A, Mantalaris A, Panoskaltsis N.J Immunol. 2023 Apr 1;210(7):895-904. doi:10.4049/jimmunol.2200836.de Janon AJ Immunol20234500710.4049/jimmunol.2200836
2. Systematic Understanding of Recent Developments in Bacterial Cellulose Biosynthesis at Genetic, Bioprocess and Product Levels., Buldum G, Mantalaris A.Int J Mol Sci. 2021 Jul 3;22(13):7192. doi: 10.3390/ijms22137192.Buldum GInt J Mol Sci20214439710.3390/ijms22137192
3. Apoptosis: A mammalian cell bioprocessing perspective.,Grilo AL, Mantalaris A.Biotechnol Adv. 2019 May-Jun; 37(3):459-475. doi: 10.1016/j.biotechadv.2019.02.012. Epub 2019 Feb 20., Grilo ALBiotechnol Adv20194352010.1016/j.biotechadv.2019.02.012
4. New Approaches to Respiratory Assist: Bioengineering an Ambulatory, Miniaturized Bioartificial., LungNovosel E, Borchers K, Kluger PJ, Mantalaris A, Matheis G, Pistolesi M, Schneider J, Wenz A, Lelkes PI.ASAIO J. 2019 Jul;65(5):422-429. doi: 10.1097/MAT.0000000000000841
5. Nanosensors for regenerative medicine. Yeo DC, Wiraja C, Mantalaris A, Xu C.J Biomed Nanotechnol. 2014 Oct;10(10):2722-46. doi: 10.1166/jbn.2014.1992.Yeo DCJ Biomed Nanotechnol20144214510.1166/jbn.2014.1992
6. Osteoinduction: translating preclinical promise into clinical reality. Ferretti C, Ripamonti U, Tsiridis E, Kerawala CJ, Mantalaris A, Heliotis M.Br J Oral Maxillofac Surg. 2010 Oct;48(7):536-9. doi: 10.1016/j.bjoms.2009.08.043. Epub 2010 Apr 28.Ferretti CBr J Oral Maxillofac Surg20104029910.1016/j.bjoms.2009.08.043
7. Investigational drugs for fracture healing: preclinical & clinical data. Klontzas ME, Kenanidis EI, MacFarlane RJ, Michail T, Potoupnis ME, Heliotis M, Mantalaris A, Tsiridis E.Expert Opin Investig Drugs. 2016;25(5):585-96. doi: 10.1517/13543784.2016.1161757. Epub 2016 Mar 28. Klontzas MEExpert Opin InvestigDrugs20164243310.1517/13543784.2016.1161757
8. Designing a bio-inspired biomimetic in vitro system for the optimization of ex vivo studies of pancreatic cancer. Totti S, Vernardis SI, Meira L, Pérez-Mancera PA, Costello E, Greenhalf W, Palmer D, Neoptolemos J, Mantalaris A, Velliou EG.Drug Discov Today. 2017 Apr; 22(4):690-701. doi: 10.1016/j.drudis.2017.01.012. Epub 2017 Jan 30. Totti SDrug DiscovToday20174277010.1016/j.drudis.2017.01.012
9. Bone and cartilage regeneration with the use of umbilical cord mesenchymal stem cells. Klontzas ME, Kenanidis EI, Heliotis M, Tsiridis E, Mantalaris A. Expert Opin Biol Ther. 2015;15(11):1541-52. doi: 10.1517/14712598.2015.1068755. Epub 2015 Jul 15. Klontzas MEExpertOpin BiolTher20154220110.1517/14712598.2015.1068755
10. Current clinical evidence for the use of mesenchymal stem cells in articular cartilage repair. Reissis D, Tang QO, Cooper NC, Carasco CF, Gamie Z, Mantalaris A, Tsiridis E.Expert Opin BiolTher. 2016;16(4):535-57. doi: 10.1517/14712598.2016.1145651. Epub 2016 Feb 20. Reissis DExpertOpin Biol Ther20164239210.1517/14712598.2016.1145651
11. Skeletal tissue engineering using mesenchymal or embryonic stem cells: clinical and experimental data. Gamie Z, MacFarlane RJ, Tomkinson A, Moniakis A, Tran GT, Gamie Y, Mantalaris A, TsiridisE.Expert Opin Biol Ther. 2014 Nov;14(11):1611-39. doi: 10.1517/14712598.2014.945414.Gamie ZExpert Opin Biol Ther20144192310.1517/14712598.2014.945414
12. Engineering a mimicry of bone marrow tissue ex vivo. Panoskaltsis N, Mantalaris A, Wu JH.J Biosci Bioeng. 2005 Jul;100(1):28-35. doi: 10.1263/jbb.100.28.Panoskaltsis NJ Biosci Bioeng20053864510.1263/jbb.100.28
13. TGF-beta3: A potential biological therapy for enhancing chondrogenesis. Tang QO, Shakib K, Heliotis M, Tsiridis E, Mantalaris A, Ripamonti U, Tsiridis E.Expert Opin BiolTher. 2009 Jun;9(6):689-701. doi: 10.1517/14712590902936823.Tang QOExpert Opin BiolTher20093994510.1517/14712590902936823
14. More than meets the eye in bacterial cellulose: biosynthesis, bioprocessing, and applications in advanced fiber composites. Lee KY, Buldum G, Mantalaris A, Bismarck A.Macromol Biosci. 2014 Jan;14(1):10-32. doi: 10.1002/mabi.201300298. Epub 2013 Jul 30. Lee KYMacromolBiosci20144148610.1002/mabi.201300298
15. The basic science of bone induction. Heliotis M, Ripamonti U, Ferretti C, Kerawala C, Mantalaris A, Tsiridis E.Br J Oral Maxillofac Surg. 2009 Oct;47(7):511-4. doi: 10.1016/j.bjoms.2009.01.013. Epub 2009 Mar 10.Heliotis MBr J Oral Maxillofac Surg20093988510.1016/j.bjoms.2009.01.013
16. Stem cell bioprocessing: fundamentals and principles. Placzek MR, Chung IM, Macedo HM, Ismail S, Mortera Blanco T, Lim M, Cha JM, Fauzi I, Kang Y, Yeo DC, Ma CY, Polak JM, Panoskaltsis N, Mantalaris A.J R Soc Interface. 2009 Mar 6;6(32):209-32. doi: 10.1098/rsif.2008.0442.Placzek MRJ R Soc Interface 20093977910.1098/rsif.2008.0442
17. Biological therapy of bone defects: the immunology of bone allo-transplantation. Graham SM, Leonidou A, Aslam-Pervez N, Hamza A, Panteliadis P, Heliotis M, Mantalaris A, TsiridisE.Expert Opin Biol Ther. 2010 Jun;10(6):885-901. doi: 10.1517/14712598.2010.481669. Graham SMExpert Opin Biol Ther 20104029510.1517/14712598.2010.481669
18. Investigating the role of PDGF as a potential drug therapy in bone formation and fracture healing. Graham S, Leonidou A, Lester M, Heliotis M, Mantalaris A, Tsiridis E.Expert Opin Investig Drugs. 2009 Nov;18(11):1633-54. doi: 10.1517/13543780903241607. Graham S Expert Opin Investig Drugs 20094007110.1517/13543780903241607
19. Growth hormone: does it have a therapeutic role in fracture healing? Tran GT, Pagkalos J, Tsiridis E, Narvani AA, Heliotis M, Mantalaris A, Tsiridis E.Expert Opin InvestigDrugs. 2009 Jul;18(7):887-911. doi: 10.1517/13543780902893069. Tran GTExpert Opin Investig Drugs 20093996610.1517/13543780902893069
20. Perspectives in regenerative medicine and tissue engineering of bone. Ripamonti U, Tsiridis E, Ferretti C, Kerawala CJ, Mantalaris A, Heliotis M.Br J Oral Maxillofac Surg. 2011 Oct;49(7):507-9. doi: 10.1016/j.bjoms.2010.07.020. Epub 2010 Dec 7.Ripamonti UBr J Oral Maxillofac Surg20114052710.1016/j.bjoms.2010.07.020
21. Bioprocess systems engineering: transferring traditional process engineering principles to industrial biotechnology. Koutinas M, Kiparissides A, Pistikopoulos EN, Mantalaris A.Comput Struct Biotechnol J. 2013 Mar 10; 3:e201210022. doi: 10.5936/csbj.201210022. eCollection 2012. Koutinas MComput Struct Biotechnol J20134173110.5936/csbj.20121002
22. The potential adverse effects of aromatase inhibitors on wound healing: in vitro and in vivo evidence. Howgate DJ, Gamie Z, Panteliadis P, Bhalla A, Mantalaris A, Tsiridis E.Expert Opin Drug Saf. 2009 Sep;8(5):523-35. doi: 10.1517/14740330903190674.Howgate DJExpert Opin Drug Saf20094002910.1517/14740330903190674
23. Prostaglandin E(2) receptors as potential bone anabolic targets - selective EP4 receptor agonists. Pagkalos J, Leonidou A, As-Sultany M, Heliotis M, Mantalaris A, Tsiridis E.Curr Mol Pharmacol. 2012 Jun;5(2):174-81. doi: 10.2174/1874467211205020174.Pagkalos JCurr Mol Pharmacol20124075110.2174/1874467211205020174
24. Intelligent bioprocessing for haemotopoietic cell cultures using monitoring and design of experiments. Lim M, Ye H, Panoskaltsis N, Drakakis EM, Yue X, Cass AE, Radomska A, Mantalaris A.BiotechnolAdv. 2007 Jul-Aug; 25(4):353-68. doi: 10.1016/j.biotechadv.2007.02.002. Epub 2007 Feb 15. Lim MBiotechnol Adv20073918510.1016/j.biotechadv.2007.02.002
25. Prostaglandin EP2 and EP4 receptor agonists in bone formation and bone healing: In vivo and in vitro evidence. Graham S, Gamie Z, Polyzois I, Narvani AA, Tzafetta K, Tsiridis E, Helioti M, Mantalaris A, Tsiridis E.Expert Opin Investig Drugs. 2009 Jun;18(6):746-66. doi: 10.1517/13543780902893051. Graham S Expert Opin Investig Drugs 20093994510.1517/13543780902893051
26. Stem cells combined with bone graft substitutes in skeletal tissue engineering. Gamie Z, Tran GT, Vyzas G, Korres N, Heliotis M, Mantalaris A, Tsiridis E.Expert Opin Biol Ther. 2012 Jun;12(6):713-29. doi: 10.1517/14712598.2012.679652. Epub 2012 Apr 14. Gamie ZExpert OpinBiol Ther20124101610.1517/14712598.2012.679652
27. Preclinical and clinical data for the use of mesenchymal stem cells in articular cartilage tissue engineering. Tang QO, Carasco CF, Gamie Z, Korres N, Mantalaris A, Tsiridis E.Expert Opin Biol Ther. 2012 Oct;12(10):1361-82. doi: 10.1517/14712598.2012.707182. Epub 2012 Jul 12. Tang QOExpert OpinBiol Ther20124110310.1517/14712598.2012.707182
28. Anti-inflammatory role and immunomodulation of mesenchymal stem cells in systemic joint diseases: potential for treatment. MacFarlane RJ, Graham SM, Davies PS, Korres N, Tsouchnica H, Heliotis M, Mantalaris A, Tsiridis E. Expert Opin Ther Targets. 2013 Mar;17(3):243-54. doi: 10.1517/14728222.2013.746954. Epub 2013 Jan 8. MacFarlane RJExpert Opin Ther Targets20134128310.1517/14728222.2013.746954
29. Disease-modifying osteoarthritis drugs: in vitro and in vivo data on the development of DMOADs under investigation. Davies PS, Graham SM, MacFarlane RJ, Leonidou A, Mantalaris A, Tsiridis E.Expert Opin InvestigDrugs. 2013 Apr;22(4):423-41. doi: 10.1517/13543784.2013.770837. Epub 2013 Feb 14. Davies PSExpert Opin InvestigDrugs20134132110.1517/13543784.2013.770837
30. Investigating the role of PDGF as a potential drug therapy in bone formation and fracture healing . c(Journal Article, Review), recordstatus REVIEWExpert Opin InvestigDrugs.,2009 Nov;18(11):1633-54.
31. Biological therapy of bone defects: the immunology of bone allo-transplantation c(Journal Article, Review), recordstatus REVIEWExpert Opin Biol Ther.,2010 Jun;10(6):885-901.,doi: 10.1517/14712598.2010.481669.
32. Bioprocess systems engineering: transferring traditional process engineering principles to industrial biotechnology. c(Journal Article, Review), recordstatus REVIEWComput Struct Biotechnol J.,2013 Mar 10:3:e201210022.doi: 10.5936/csbj.201210022. eCollection 2012.
33. Anti-inflammatory role and immunomodulation of mesenchymal stem cells in systemic joint diseases: potential for treatment . c(Journal Article, Review), recordstatus REVIEWExpert Opin Ther Targets.,2013 Mar;17(3):243-54. doi: 10.1517/14728222.2013.746954.
34. cells bioprocessing: an important milestone to move regenerative medicine research into the clinical arena . c(Journal Article, Review), recordstatus REVIEW.,Pediatr Res.,2008 May;63(5):461-6. doi: 10.1203/pdr.0b013e31816a8c1c.
35. Prostaglandin EP2 and EP4 receptor agonists in bone formation and bone healing: In vivo and in vitro evidence. c(Journal Article, Review), recordstatus REVIEWExpert Opin InvestigDrugs.,2009 Jun;18(6):746-66.,doi: 10.1517/13543780902893051.
36. Disease-modifying osteoarthritis drugs: in vitro and in vivo data on the development of DMOADs under investigation . c(Journal Article, Review), recordstatus REVIEW Expert Opin InvestigDrugs.,2013 Apr;22(4):423-41.
37. Investigational drugs for fracture healing: preclinical & clinical data c(Journal Article, Review), record status REVIEW Expert Opin Investig Drugs. ,2016;25(5):585-96. doi: 10.1517/13543784.2016.1161757.
38. Designing a bio-inspired biomimetic in vitro system for the optimization of ex vivo studies of pancreatic cancer. c(Journal Article, Review), recordstatus REVIEW Drug Discov Today.,2017 Apr;22(4):690-701.
39. Systematic Understanding of Recent Developments in Bacterial Cellulose Biosynthesis at Genetic, Bioprocess and Product Levels. c(Journal Article, Review), recordstatus REVIEWInt J Mol Sci.,2021 Jul 3;22(13):7192. doi: 10.3390/ijms22137192.
40. The potential adverse effects of aromatase inhibitors on wound healing: in vitro and in vivo evidence. c(Journal Article, Review), recordstatus REVIEW Expert Opin Drug Saf.,doi: 10.1517/14740330903190674.
41. New Approaches to Respiratory Assist: Bioengineering an Ambulatory, Miniaturized Bioartificial Lung. c(Journal Article, Review), recordstatus REVIEWASAIO J. ,2019 Jul; 65(5):422-429. doi: 10.1097/MAT.0000000000000841.
42. Intelligent bioprocessing for haemotopoietic cell cultures using monitoring and design of experiments . c(Journal Article, Review), recordstatus REVIEW Biotechnol Adv.,2007 Jul-Aug; 25(4):353-68.
1. Development of a multi-scale model to simulate mesenchymal stem cell osteogenic differentiation within hydrogels in a rotating wall bioreactor (BOOK CHAPTER- Biochemical Engineering Journal, Volume 186, August 2022, 108566). R Győrgy, M Kostoglou, A Mantalaris, MC Georgiadis. Biochemical Engineering Journal 186, 108566, 2022. Mandates: European Commission.
2. Dynamic human erythropoiesis in a three-dimensional perfusion bone marrow biomimicry (BOOK CHAPTER- Biomaterials, Volume 188, January 2019, Pages 24-37). MC Allenby, N Panoskaltsis, A Tahlawi, SB Dos Santos, A Mantalaris. Biomaterials 188, 24-37, 2019. Mandates: Blood Cancer UK
3. Sequential and simultaneous optimization strategies for increased production of monoclonal antibodies (BOOK CHAPTER- Computer Aided Chemical Engineering, Volume 46, 2019, Pages 1021-1026). CD Kappatou, O Altunok, A Mhamdi, A Mantalaris, A Mitsos. Computer Aided Chemical Engineering 46, 1021-1026, 2019. Mandates: European Commission
4. Klontzas, M.E. and Mantalaris, A. (2019). The Use of Alginate Hydrogels for the Culture of Mesenchymal Stem Cells (MSCs): In Vitro and In Vivo Paradigms, Alginates. IntechOpen.
5. Samadikuchaksaraei, A., Lecht, S., Lelkes, P. I., Mantalaris, A., & Polak, J. M. (2013). Stem Cells as Building Blocks, Principles of Tissue Engineering: Fourth Edition: 41-55: Elsevier Inc.
6. Mondrinos, M.J., Lelkes, P. I., Samadikuchaksaraei, A., Mantalaris, A., & Polak, J. M. (2013). Lungs, Principles of Tissue Engineering: Fourth Edition: 1561-1577: Elsevier Inc.
7. Kiparissides, A., Koutinas, M., Pistikopoulos, E. N., & Mantalaris, A. (2011). Model Development and Analysis of Mammalian Cell Culture Systems, Process Systems Engineering, Vol. 7: 403-439: Wiley-VCH.
8. Siti-Ismail, N., Polak, J.M., and A. Mantalaris (2010), Lung stem cell bioprocessing: fundamentals of producing lung cells, in Cell Therapy for Lung Disease, J.M. Polak, Ed. Imperial College Press.
9. Polak, J.M. and A. Mantalaris (2008). Cell Expansion, Cell Encapsulation, 3D Cultures, in Advances in Tissue Engineering, J.M. Polak, A. Mantalaris, & S.E. Harding, Eds. Imperial College Press.
10. Lim, M. and A. Mantalaris (2008). Development of a Design of Experiment Methodology: Applications to the Design and Analysis of Experiments, in Advances in Tissue Engineering, J.M. Polak, A. Mantalaris, & S.E. Harding, Eds. Imperial College Press.
11. Lim, M., N. Panoskaltsis, and A. Mantalaris (2008). Optimal Expansion and Differentiation of Cord Blood Stem Cells Using Design of Experiments: A Case Study in Erythropoiesis, in Handbook of Cardiac Stem Cell Therapy, I. Dimarakis, P. Menasché, N.A. Habib & M.Y, Gordon, Eds. Imperial College Press.
12. Mantalaris, A. W.L. Randle, and J.M. Polak (2008). Stem cell bioprocessing for clinical applications of regenerative medicine, in Stem Cell Repair and Regeneration.
13. volume 3, N. Levičar, N.A. Habib, M.Y. Gordon & I. Dimarakis, Eds. Imperial College Press.
14. Safinia, L., N. Panoskaltsis, A. Mantalaris (2005). Bone Marrow Tissue Engineering Bioreactors, in Bioreactors for Tissue Engineering: Principles, Design and Operation, M. Al-Rubeai and J. Chaudhuri, Eds., Kluwer Academic Publishers.
15. Mantalaris, A. and J.H.D. Wu (2005). Ex Vivo Culture of Hematopoietic and Mesenchymal Stem Cells in Cell Culture Technology for Pharmaceutical and Cell-Based Therapies, S.S. Ozturk and W-S. Hu, Eds., Taylor & Francis Group, Inc.
16. Mantalaris, A., N. Panoskaltsis, J.H.D. Wu (2004). Hematopoietic Stem Cells and Assays, in Encyclopedia of Biomaterials and Biomedical Engineering, G.E. Wnek and G.L. Bowlin, Eds., Marcel Dekker, Inc.
17. Mantalaris, A., N. Panoskaltsis, J.H.D. Wu (2004). Tissue Engineering of Bone Marrow, Culture Systems, in Encyclopedia of Biomaterials and Biomedical Engineering, G.E. Wnek and G.L. Bowlin, Eds., Marcel Dekker, Inc.
18. Mantalaris, A., N. Panoskaltsis, J.H.D. Wu (2004). Tissue Engineering of Bone Marrow, in Encyclopedia of Biomaterials and Biomedical Engineering, G.E. Wnek and G.L. Bowlin, Eds., Marcel Dekker, Inc.

Prof. Nicki Panoskaltsis
List of Publications

1. Allenby MC, Okutsu N, Brailey K, Guasch J, Zhang Q, Panoskaltsis N*, Mantalaris A*. A spatiotemporal microenvironment model to improve design of a 3D bioreactor for red cell production. Tissue Eng Part A. 2021 Jun 15; PubMed PMID: 34130508. https://doi.org/10.1089/ten.TEA.2021.0028 *Joint corresponding & senior authors.
2. Dennis M, Burnett A, Hills R, Thomas I, Ariti C, Severinsen MT, Hemmaway C, Greaves P, Clark RE, Copland M, Russell N, Kallenbach M, Culligan D, Duncan C, Krishnamurthy P, Cuthbert A, Patalappa C, Spanoudakis M, Galvani D, Berkahn I, Patton N, Pemberton L, Virchis A, Jasani P, Parker A, Arnold C, Cuthbert R, Finnega D, Nikolousis M, Pratt G, Cahalin P, Ackroyd S, Mehta P, Protheroe R, Weinkove R, Ali S, Welch E, Smith M, Spearing R, Vyas P, Campbell G, Hamblin M, Wood M, Gupta S, Westonsmith S, Pillai A, Hunter H, Rule S, Neilson R, Lush R, Rothwell K, Swe W, Chalmers I, Prahladan M, Kwan M, Lyttleton M, Hunter A, Martin AM, Saravanamuttu K, Saif M, Tholouli E, Andrews V, Jackson S, Rajagopal R, Morrison A, Gordon W, Mitchell L, Bowen A, McGrann A, Mittal S, Panoskaltsis N, Byrne J, Das-Gupta E, Radia R, Baker B, Kilfoyle A, Knottenbelt E, Rinaldi C, Moreton P, Furby D, Jack F, Alderman C, Belsham E, Corser R, Cranfield T, Dignum H, James C, Gudgin E, Mohan M, Kampman P, Kjeldsen L, Mourek J, Nielsen OJ, Niemann CU, Grech H, Khan A, Sampson R, Creagh D, Szabo F, Coppell J, Veale D, Kottaridis P, Fernandes S, Cullis J, Grand E, Wandroo F, Mohite U, O’Brien D, Nicholson T, Janes S, Aitchison R, Galloway M, Mathew S, Blesing N, Green S, Mamadigi R, Plews D, Chacko J, Salim R, Allameddine A, Greenfield H, Osborne D, Hodges G, Lai HC, Carrington P, Sadik W, Yung L, Lokare A, Alvares C, Knapper S, Goodman H, Islam S, Aitchison R, Pattinson J, Pushkaran B, Heartin E, Edwards D, Seale J. A randomised evaluation of low-dose cytosine arabinoside (ara-C) plus tosedostat versus low-dose ara-C in older patients with acute myeloid leukaemia: results of the LI-1 trial. B J Hematol 2021 194(2):298-308. doi.org/10.1111/bjh.17501.
3. Panoskaltsis N*, McCarthy NE, Knight SC. Myelopoiesis of acute inflammation – lessons from TGN1412-induced cytokine storm. Cancer Immunol, Immunotherapy, 2021 70(4):1155–1160. PubMed PMID: 32862238. doi: 10.1007/ s00262-020-02702-9. *Corresponding & senior author.
4. McCarthy NE, Stagg AJ, Price CL, Mann ER, Gellatly N, Al-Hassi HO, Knight SC, Panoskaltsis N*. Patients with gastrointestinal irritability after TGN1412-induced cytokine storm displayed selective expansion of gut-homing αβ and γδT-cells. Cancer Immunol, Immunotherapy 2021 70(4):1143–1153. PubMed PMID: 33048222; PubMed Central PMCID: PMC7552579. *Corresponding & senior author.
5. Panoskaltsis N*, McCarthy NE, Stagg AJ, Husni M, Mummery CJ, Price CL, Al-Hassi HO, Greenstein D, Arebi N, Koutinas M, Mantalaris A, Knight SC. Immune reconstitution and clinical recovery following anti-CD28 antibody (TGN1412)- induced cytokine storm. Cancer Immunol, Immunotherapy 2021 70(4): 1127–1142. PubMed PMID: 33033851; PubMed Central PMCID: PMC7543968. *Corresponding & senior author.
6. Karakostas P, Panoskaltsis N, Mantalaris A, Georgiadis MC. Optimization of CAR T-cell therapies supply chains. Computers Chem Eng, 2020, 139; DOI: 10.1016/j.compchemeng.2020.106913.
7. Győrgy R, Klontzas M, Kostoglou M, Panoskaltsis N, Mantalaris A, Georgiadis MC. Capturing mesenchymal stem cell heterogeneity during osteogenic differentiation: an experimental–modelling approach. Ind Eng Chem. Res, 2019. doi: 10.1021/acs.iecr.9b01988
8. Klontzas ME, Reakasame S, Silva R, Morais JC, Vernardis S, MacFarlane RJ, Heliotis M, Tsiridis E, Panoskaltsis N, Boccaccini AR, Mantalaris A. Oxidized alginate hydrogels with the GHK peptide enhance cord blood mesenchymal stem cell osteogenesis: a paradigm for metabolomics-based evaluation of biomaterial design. Acta Biomaterialia 2019 88:224-240. doi: 10.1016/j.actbio.2019.02.017.
9. Tahlawi A, Klontzas ME, Allenby MC, Morais JC, Panoskaltsis N, Mantalaris A. RGD-functionalized polyurethane scaffolds promote umbilical cord blood mesenchymal stem cell expansion and osteogenic differentiation. J Tissue Eng Regen Med 2019 13(2):232-243. doi:10.1002/term.2784.
10. Allenby MC, Panoskaltsis N*, Tahlawi A, Brito Dos Santos S, Mantalaris A*. Dynamic human erythropoiesis in a three- dimensional perfusion bone marrow biomimicry. Biomaterials, 2019 188:24-37. *Joint corresponding & senior authors.
11. Allenby M, Tahlawi A, Morais JCF, Li K, Panoskaltsis N*, Mantalaris A*. Ceramic hollow fibre constructs for continuous perfusion and cell harvest from 3D hematopoietic organoids. Stem Cells International 2018:6230214. doi: 10.1155/2018/6230214. *Joint corresponding & senior authors.
12. Quiroga-Campano A, Panoskaltsis N, Mantalaris A. Energy-based culture medium design for biomanufacturing optimization: a case study in monoclonal antibody production by GS-NS0 cells. Metabolic Engineering 2018 47:21-30.
13. An Integrated Experimental-Modelling Approach of Mesenchymal Stem Cell Bioprocess towards Osteogenic Differentiation.,R Győrgy, ME Klontzas, M Kostoglou, N Panoskaltsis, MC Georgiadis.,IFAC-PapersOnLine 50 (1), 9877- 9882, 2017.,Mandates: European Commission.
14. Misener R, Allenby MC, Fuentes-Gari M, Gupta K, Wiggins T, Panoskaltsis N, Pistikopoulos EN, Mantalaris A. Stem cell biomanufacturing under uncertainty: a case study in optimizing red blood cell production. AIChE Journal 2017. http:// onlinelibrary.wiley.com/doi/10.1002/aic.16042/full.
15. Harrison C, Mead AJ, Panchal A, Fox S, Yap C, Gbandi E, Houlton A, Aliman S, Ewing J, Wood M, Chen F, Coppell J, Panoskaltsis N, Knapper S, Ali S, Hamblin A, Scherber R, Dueck AC, Cross N, Mesa R, McMullin MF. Ruxolitinib vs best available therapy for ET intolerant or resistant to hydoxycarbamide in a randomized trial. Blood 2017 130:1889-1897; doi: https://doi.org/10.1182/blood-2017-05-785790.
16. Allenby MC, Misener R, Panoskaltsis N, Mantalaris A. A quantitative three-dimensional (3D) image analysis tool for maximal acquisition of spatial heterogeneity data. Tissue Eng Part C Methods 2017;23(2):108-117.
17. Vernardis SE, Mantalaris A, Panoskaltsis N. Human embryonic and induced pluripotent stem cells maintain phenotype but alter their metabolism after exposure to ROCK inhibitor. Scientific Reports 2017;7:42138, doi:10.1038/srep42138.
18. Chaudhry MS, Gilmour KC, House IG, Panoskaltsis N, Sohal M, Trapani JA, Layton M, Voskoboinik I. Missense mutations in the human perforin (PRF1) gene as a cause of hereditary cancer predisposition. OncoImmunology. 2016;5(7):5 pages, ARTN e1179415. DOI:10.1080/2162402X.2016.1179415.
19. Savvopoulos S, Misener R, Panoskaltsis N, Pistikopoulos EN, Mantalaris A. A personalized framework for dynamic modelling of disease trajectories in chronic lymphocytic leukemia. IEEE Trans Biomed Eng (TBME). 2016;63(11):2396- 2404.
20. Fuentes-Garí M, Misener R, Georgiadis MC, Kostoglou M, Panoskaltsis N, Mantalaris A, Pistikopoulos EN. Selecting a Differential Equation Cell Cycle Model for Simulating Leukemia Treatment. Ind Eng Chem Res. 2015;54(36):8847– 8859.
21. Fuentes-Garí M, Misener R, Pefani E, García-Münzer D, Kostoglou M, Georgiadis MC, Panoskaltsis N, Pistikopoulos EN, Mantalaris A. Cell cycle model selection for leukemia and its impact in chemotherapy outcomes. Computer Aided Chemical Eng. 2015;37:2159-2164.
22. Chemotherapy optimization in leukemia: selecting the right mathematical models for the right biological processes**.,M Fuentes-Garí, R Misener, MC Georgiadis, M Kostoglou, N Panoskaltsis, IFAC-PapersOnLine 48 (20), 534-539, 2015.,Mandates: Blood Cancer UK.
23. Kostoglou M, Fuentes-Garí M, García-Münzer D, Georgiadis MC, Panoskaltsis N, Pistikopoulos EN, Mantalaris A. Mathematical analysis of multistage population balances for cell growth and death. Computer Aided Chem Eng. 2015;37:2105-2110.
24. Velliou EG, Dos Santos SB, Papathanasiou MM, Fuentes-Gari M, Misener R, Panoskaltsis N, Pistikopoulos EN, Mantalaris A. Towards unravelling the kinetics of an acute myeloid leukaemia model system under oxidative and starvation stress: a comparison between two- and three-dimensional cultures. Bioprocess Biosystems Eng. 2015;38(8):1589- 1600.
25. Fuentes-Gari M, Velliou E, Misener R, Pefani E, Rende M, Panoskaltsis N, Mantalaris, A, Pistikopoulos EN. A systematic framework for the design, simulation and optimization of personalized healthcare: Making and healing blood. Computers Chem Eng. 2015;81(SI):80-93.
26. Fuentes-Gari M, Misener R, Garcia Munzer D, Velliou E, Georgiadis MC, Kostoglou M, Pistikopoulos EN, Panoskaltsis N*, Mantalaris A*. A mathematical model of subpopulation kinetics for the deconvolution of leukaemia heterogeneity. J R Soc Interface. 2015;12(108). http://dx.doi.org/10.1098/rsif.2015.0276. *Joint corresponding & senior authors.
27. Dennis M, Russell N, Hills R, Hemmaway C, Panoskaltsis N, McMullin MF, Kjeldsen L, Dignum H, Thomas I, Clark R, Milligan D, Burnett A. Randomised Assessment of Vosaroxin with or without Low Dose Ara-C (LDAC) versus LDAC in Older patients with Acute Myeloid Leukaemia. Blood. 2015;125(9):2923-2932.
28. Burnett A, Russell N, Hills R, Panoskaltsis N, Khwaja A, Hemmaway C, Cahalin P, Clark R, Milligan D. A Randomised Comparison of the Novel Nucleoside Analogue Sapacitabine with Low Dose Cytarabine in Older patients with Acute Myeloid Leukaemia. Leukemia. 2015;29:1312-1319.
29. Misener R, Fuentes Garí M, Rende M, Velliou E, Panoskaltsis N, Pistikopoulos EN, Mantalaris A. Global superstructure optimisation of red blood cell production in a parallelised hollow fibre bioreactor. Computers Chem Eng. 2014;71:532- 553.
30. Fauzi I, Panoskaltsis N*, Mantalaris A*. Early exposure of murine embryonic stem cells to hematopoietic cytokines differentially directs definitive erythropoiesis and cardiomyogenesis in alginate hydrogel three-dimensional cultures. Stem Cells Devel. 2014;23(12):2720-2729. *Joint corresponding & senior authors.
31. Pefani E, Panoskaltsis N, Mantalaris A, Georgiadis MC, Pistikopoulos EN. Chemotherapy Drug Scheduling for the Induction Treatment of patients with Acute Myeloid Leukemia. IEEE Trans Biomed Eng. 2014;61(7):2049-2056.
32. Krieger A, Panoskaltsis N, Mantalaris A, Georgiadis MC, Pistikopoulos EN. Modeling and Analysis of Individualized Pharmacokinetics and Pharmacodynamics for Volatile Anesthesia. IEEE Trans Biomed Eng. 2014;61(1):25-34.
33. Pefani E, Panoskaltsis N, Mantalaris A, Georgiadis MC, Pistikopoulos E. Design of optimal patient-specific chemotherapy protocols for the treatment of Acute Myeloid Leukemia (AML). Computers Chem Eng. 2013;57:187-195.
34. Morgan GJ, Davies FE, Gregory WM, Bell SE, Szubert AJ, Coy NN, Cook G, Feyler S, Johnson PRE, Rudin C, et al [Group Author: NCRI Haematological Oncology]. Cyclophosphamide, thalidomide, and dexamethasone as induction therapy for newly diagnosed multiple myeloma patients destined for autologous stem-cell transplantation: MRC Myeloma IX randomized trial results. Haematologica. 2012. 97(30):442-450. DOI: 10.3324/haematol.2011.043372.
35. Morgan GJ, Davies FE, Gregory WM, Szubert AJ, Bell SE, Drayson MT, Owen RG, Ashcroft AJ, Jackson GH, Child JA, et al [Group Author: Natl Canc Res Inst Haematological]. Effects of induction and maintenance plus long-term bisphosphonates on bone disease in patients with multiple myeloma: the Medical Research Council Myeloma IX Trial. Blood. 2012;119(23):5374-5383. DOI: 10.1182/blood-2011-11-392522.
36. Fauzi I, Panoskaltsis N*, Mantalaris A*. Enhanced hematopoietic differentiation towards erythrocytes from murine embryonic stem cells with HepG2-conditioned medium. Stem Cells Devel. 2012;21(17):3152-3161. *Joint corresponding & senior authors.
37. Lim M, Chua S, Panoskaltsis N*, Mantalaris A*. Systematic experimental design for bioprocess characterization: elucidating transient effects of multi-cytokine contributions on erythroid differentiation. Biotech Bioprocess Eng. 2012;17(1):218-226. *Joint corresponding & senior authors.
38. Ma CYJ, Panoskaltsis N, Kumar R, Xu XY, Mantalaris A. Simulation of ex vivo bone marrow culture: Application to chronic myeloid leukaemia growth model. Biochem Eng Journal. 2012;61:66-77.Mortera-Blanco T, Rende M, Macedo H, Farah S, Bismarck A, Mantalaris A, Panoskaltsis N. Ex vivo mimicry of normal and abnormal human hematopoiesis. Journal of Visualized Experiments (JoVE). 2012, e3654, DOI:10.3791/3654; http://www.jove.com/video/3654.
39. Mortera-Blanco T, Mantalaris A*, Bismarck A, Aqel N, Panoskaltsis N*. Long-term cytokine-free expansion of cord blood mononuclear cells in three-dimensional scaffolds. Biomaterials. 2011;32:9263-9270. *Joint corresponding & senior authors.
40. Mortera Blanco T, Mantalaris A*, Bismarck A, Panoskaltsis N*. Development of a three-dimensional scaffold for ex vivo biomimicry of human acute myeloid leukaemia. Biomaterials. 2010;31(8):2243-2251. *Joint corresponding & senior authors.
41. Burnett AK, Milligan D, Goldstone A, Prentice A, McMullin MF, Dennis M, Sellwood E, Pallis M, Russell N, Hills RK, et al [Group Author: United Kingdom Natl Canc Res Inst.]. The impact of dose escalation and resistance modulation in older patients with acute myeloid leukaemia and high risk myelodysplastic syndrome: the results of the LRF AML14 trial. Brit J Haem 2009;145(3):318-332.
42. Lim M, Ye H, Drakakis EM, Yue XC, Cass AEG, Panoskaltsis N, Mantalaris A. Towards information-rich bioprocessing: Generation of spatio-temporal profiles through the use of design of experiments to determine optimal number and location of sensors – an example in thermal profiles. Biochem Eng Journal 2008;40(1):1-7.
43. Xicai Y, Drakakis EM, Lim M, Radomska A, Hua Y, Mantalaris A, Panoskaltsis N, Cass A. A real-time multi-channel monitoring system for stem cell culture process. IEEE Trans Biomed Circ Systems. 2008;2(2):66-77.
44. Kumar R, Panoskaltsis N, Stepanek F, Mantalaris A. Coupled oxygen-carbon dioxide transport model for the human bone marrow. Food Bioprod Process 2008;86(C3): 211-219.
45. Lim M, Ye H, Panoskaltsis N, Drakakis E, Yue A, Toumazou C, Cass A, Radomska A, Mantalaris A. Intelligent bioprocessing for haematopoietic cell cultures using monitoring and design of experiments. Biotech Advances 2007;25(4): 353-368.
46. GM1-gangliosidosis type I. Pavlu J, Jackson M, Panoskaltsis N. Brit J Haem 2006;135(4):422.
47. Suntharalingam G*, Perry MR, Ward, S, Brett SJ, Castello-Cortes A, Brunner MD, Panoskaltsis N*. Cytokine storm in phase 1 trial of the anti-CD28 monoclonal antibody TGN1412. N Engl J Med 2006; 355:1018-1028. (>1500 citations to date) Joint corresponding authors.
48. Pavlu J, Panoskaltsis N. Dysplastic polychromatic “snowmoblast”. Blood. 2005;106(12):3689.
49. Panoskaltsis N, Reid CDL, Knight SC. Quantification and cytokine production of circulating lymphoid and myeloid cells in acute myelogenous leukemia (AML). Leukemia 2003;17:716-730.
50. Panoskaltsis N, Belanger TJ, Liesveld JL, Abboud CN. Optimal cytokine stimulation for the enhanced generation of leukemic dendritic cells in short-term culture. Leuk Res 2002; 26(2):191-201.
51. Liesveld JL, Rosell K, Panoskaltsis N, Belanger T, Harbol A, Abboud CN. Response of human CD34+ cells to CXC, CC, and CX3C chemokines: implications for cell migration and activation. J Hematother Stem Cell Res 2001;10:643-655.
52. Mantalaris A, Panoskaltsis N, Sakai Y, Bourne P, Chang C, Messing EM, Wu JHD. Localization of androgen receptor expression in human bone marrow. J Pathol 2001; 193:361-366.
53. Panoskaltsis N. Claudication with normal pulses. N Eng J Med. 1996;335(2):1686.
1. Murnane C, Gardiner N, Crehan O, Bacon CL, McHugh R, Gilmer JF, Mantalaris A*, Panoskaltsis N*. Chimeric Antigen Receptor-T (CAR-T) Cells as “Living Drugs” - a Clinical Pharmacist Perspective. Journal of Clinical Pharmacy & Therapeutics 2024; Article ID 2239888. *Joint corresponding & senior authors.
2. De Janon A, Mantalaris A, Panoskaltsis N. Three-dimensional human bone marrow organoids for the study and application of normal and abnormal hematoimmunopoiesis. J Immunol. 2023;210(7):895-904.
3. Panoskaltsis, N. Are all cytokine storms the same? Cancer Immunol Immunother 2021 70(4):887–892. https://doi.org/10.1007/s00262-020-02822-2.
4. Placzek M.R., Chung I.M., Macedo H.M., Ismail S., Blanco T.M., Lim M., Cha J.M., Fauzi I., Kang Y., Yeo D.C.L., Ma C.Y.J., Polak J.M., Panoskaltsis N., Mantalaris A. Stem cell bioprocessing: fundamentals and principles. J R Soc Interface. 2009;6(32):209-232.
5. Panoskaltsis N, Mantalaris A, Wu JHD. Engineering and mimicry of the bone marrow tissue ex vivo. J Biosci Bioeng 2005;100(1):28-35.
6. Panoskaltsis N. Dendritic cells in MDS and AML – cause, effect or solution to the immune pathogenesis of disease? Leukemia 2005;19:354-357.
7. Panoskaltsis N, Reid CDL, Knight SC. Immune modulation with dendritic cells. Transfusion Med 2004; 14(2):81-96.
8. Panoskaltsis N, Derman MP, Perillo I, Brennan JK. Thrombotic thrombocytopenic purpura in pulmonary-renal syndromes. Amer J Hematol. 2000;65(1):50-55.
9. Panoskaltsis N & Abboud CN. Human immunodeficiency virus and the hematopoietic repertoire: implications for gene therapy. Frontiers in Bioscience. 1999;4:d457-467.
1. Cell cycle model selection for leukemia and its impact in chemotherapy outcomes (BOOK CHAPTER).,M Fuentes-Garí, R Misener, E Pefani, D García-Münzer, M Kostoglou.,Computer Aided Chemical Engineering 37, 2159-2164, 2015.,Mandates: Blood Cancer, UK.
2. Global sensitivity analysis for a model of b-cell chronic lymphocytic leukemia disease trajectories (BOOK CHAPTER- Computer Aided Chemical Engineering, Volume 37, 2015, Pages 185-190).,S Savvopoulos, R Misener, N Panoskaltsis, EN Pistikopoulos, Computer Aided Chemical Engineering 37, 185-190, 2015.,Mandates: National Institute for Health Research, UK.
3. Mortera-Blanco T, Rende M, Panoskaltsis N, Mantalaris A. Tissue engineering of normal and abnormal bone marrow. I: Murray Moo-Young, Editors. Comprehensive Biotechnology (Third Edition), Pergamon, 2019, pp. 225–235. 5.17 - Tissue Engineering of Normal and Abnormal Bone Marrow. ISBN 9780444640475, https://doi.org/10.1016/B978-0-12-801238-3.99810-6.
4. Allenby MC, Brito dos Santos S, Panoskaltsis N, Mantalaris A. Differentiation of Human Pluripotent Stem Cells for Red Blood Cell Production. In: Cabral JMS, Lobato da Silva C, Editors. Bioreactors for Stem Cell Expansion and Differentiation. Boca Raton: CRC Press, 2018, Chapter 3. eBook ISBN 9780429841828.
5. Fauzi I, Panoskaltsis N, Mantalaris A. (2015) In vitro differentiation of embryonic stem cells into hematopoietic lineage: Towards erythroid progenitor’s production. In: Turksen K. (eds) Embryonic Stem Cell Protocols. Methods in Molecular Biology, vol 1341. Humana Press, New York, NY. https://doi.org/10.1007/7651_2015_218
6. Mortera Blanco T, Panoskaltsis N, Mantalaris A. Tissue engineering of normal and abnormal bone marrow. C-F Cui, Editor. Comprehensive Biotechnology (2nd Ed.). Elsevier, 2011, Volume 5: pp331-349. doi:10.1016/B978-0-08-088504-9.00510-9.
7. Lim M, Ye H, Panoskaltsis N, Mantalaris A. Optimal expansion and differentiation of cord blood stem cells using design of experiments: a case study on erythropoiesis. In: I. Dimarakis, M.Y. Gordon & N.A. Habib, Editors. Handbook of Cardiac Stem Cell Therapy. Imperial College Press, 2008, pp265-283.
8. Safinia L, Panoskaltsis N, Mantalaris A. Hematopoietic culture systems. In: Al-RubeaiM and Chaudhuri J, editors. Bioreactors for Tissue Engineering: Principles, Design and Operation. Kluwer Academic Publishers, 2005, pp 309-334.
9. Mantalaris A, Panoskaltsis N, Wu JHD. Tissue engineering of bone marrow: culture systems. In: Wnek G and Bowlin G, editors. Encyclopaedia of Biomaterials and Biomedical Engineering. New York: Marcel Dekker, Inc., 2004.
10. Mantalaris A, Panoskaltsis N, Wu JHD. Tissue engineering of bone marrow. In: Wnek G and Bowlin G, editors. Encyclopaedia of Biomaterials and Biomedical Engineering. New York: Marcel Dekker, Inc., 2004.
11. Mantalaris A, Panoskaltsis N, Wu JHD. Hematopoietic stem cell sources and assays. In: Wnek G and Bowlin G, editors. Encyclopaedia of Biomaterials and Biomedical Engineering. New York: Marcel Dekker, Inc., 2004.

Rest of the Team
Selected Publications

Selected Academic Publications (in chronological order)
1. “Dietary Amino Acids, Carbohydrates, Vaginal Birth and Breastfeeding are associated with the Vaginal Microbiome in Early Pregnancy” by Gillian Corbett, Rebecca Moore, Conor Feehily, Sarah Louise Killeen, Eileen O'Brien, Douwe van Sinderen, Elizabeth Matthews, Roisin O'Flaherty, Pauline Rudd, Radka Saldova, David MacIntyre, Siobhan Corcoran, Paul Cotter, and Fionnuala McAuliffe Microbiology Spectrum (in print)
2. Günay B, Matthews E, Morgan J, Tryfonidou MA, Saldova R, Pandit A. An insight on the N-glycome of notochordal cell-rich porcine nucleus pulposus during maturation. FASEB Bioadv. (2023) 8;5(8):321-335. doi: 10.1096/fba.2023-00011. PMID: 37554546; PMCID: PMC10405234.
3. Feehily C, O’Neill I, Walsh C, Moore R, Killeen S, Geraghty A, Lawton E, Byrne D, Sanchez-Gallardo R, Nielsen I, Matthews E, O’Flaherty R, Rudd PM, Groeger D, Shanahan F, Saldova R, McAuliffe F, Van Sinderen D, Cotter PD. Detailed mapping of Bifidobacterium strain transmission from mother to infant via a dual culture-based and metagenomic approach. Nat Commun 14, 3015 (2023).
4. Grelet C, Larsen T, Crowe MA, Wathes DC, Ferris CP, Ingvartsen KL, Marchitelli C, Becker F, Vanlierde A, Leblois J, Schuler U, Auer FJ, Köck A, Dale L, Sölkner J, Christophe O, Hummel J, Mensching A, Pierna JAF, Soyeurt H, Calmels M, Reding R, Gelé M, Chen Y, Gengler N; GplusE consortium, Dehareng F. Prediction of key milk biomarkers in dairy cows through milk MIR spectra and international collaborations. J Dairy Sci. (2023)
5. Foldager L, Gaillard C, Sorensen MT, Larsen T, Matthews E, O'Flaherty R, Carter F, Crowe MA, Grelet C, Salavati M, Hostens M, Ingvartsen KL, Krogh MA; GplusE Consortium. Predicting physiological imbalance in Holstein dairy cows by three different sets of milk biomarkers. Prev Vet Med. 2020 Jun; 179:105006.
6. Grelet C, Froidmont E, Foldager L, Salavati M, Hostens M, Ferris CP, Ingvartsen KL, Crowe MA, Sorensen MT, Fernandez Pierna JA, Vanlierde A, Gengler N; GplusE Consortium*, Dehareng F. Potential of milk mid-infrared spectra to predict nitrogen use efficiency of individual dairy cows in early lactation. J Dairy Sci. 2020 May;103(5):4435-4445.
7. Krogh MA, Hostens M, Salavati M, Grelet C, Sorensen MT, Wathes DC, Ferris CP, Marchitelli C, Signorelli F, Napolitano F, Becker F, Larsen T, Matthews E, Carter F, Vanlierde A, Opsomer G, Gengler N, Dehareng F, Crowe MA, Ingvartsen KL, Foldager L. Between- and within-herd variation in blood and milk biomarkers in Holstein cows in early lactation. Animal. 2020 May; 14(5):1067-1075.
8. Mooney CT, Shiel RE, Fawcett K, Matthews E, Gunn E. A comparison of canine whole and intact parathyroid hormone concentrations as measured by different assays. J Small Anim Pract. 2019 Aug;60(8):507-513.
9. De Koster J, Salavati M, Grelet C, Crowe MA, Matthews E, O'Flaherty R, Opsomer G, Foldager L; GplusE, Hostens M. Corrigendum to "Prediction of metabolic clusters in early-lactation dairy cows using models based on milk biomarkers" (J. Dairy Sci. 102:2631-2644). J Dairy Sci. 2019 Apr;102(4):3778. doi: 10.3168/jds.2019-102-4-3778. Erratum for: J Dairy Sci. 2019 Mar;102(3):2631-2644. PMID: 30878076.
10. De Koster J, Salavati M, Grelet C, Crowe MA, Matthews E, O'Flaherty R, Opsomer G, Foldager L; GplusE, Hostens M. Prediction of metabolic clusters in early-lactation dairy cows using models based on milk biomarkers. J Dairy Sci. 2019 Mar;102(3):2631-2644.
11. De Koster J, Salavati M, Grelet C, Crowe MA, Matthews E, O'Flaherty R, Opsomer G, Foldager L; GplusE, Hostens M. Prediction of metabolic clusters in early-lactation dairy cows using models based on milk biomarkers. J Dairy Sci. 2019 Mar;102(3):2631-2644.
12. Matthews E, Royle L, Corfield A, Berry M, Rudd PM, Dwek RA and Carrington SD “Glycan structures of ocular surface mucins in man, rabbit and dog display species differences.” (2008) Glycoconjugate Journal Nov; 25(8):763-73. (Co Authored)
13. Tierney JB, Matthews E, Carrington SD, and Mulcahy G. (2007) ”Interaction of Eimeria tenella with intestinal mucin in vitro.” (2007) Parasitology Jun; 93(3):634-8.
14. Matthews E, Corfield A, Gierow J.P and Carrington S.D. “Degradation of the Tear film Gel Layer” (2005) ‘Investigative Ophthalmology and Visual Science (Abstracts), 3, (1).
15. Irwin JA, Morrissey PE, Ryan JP, Walshe A, O'Neill SM, Carrington SD, Matthews E, Fitzpatrick E, Mulcahy G, Corfield AP, and Dalton JP. “Glycosidase activity in the excretory-secretory products of the liver fluke, Fasciola hepatica.” (2004) Parasitology.Oct; 129(Pt 4):465-72.
16. Matthews E, Dukes E, Hicks S, Gierow P, Irwin J, Corfield A and Carrington S.D.” Lacrimal glycosidases degrade ocular surface mucins” (2001) Investigative Ophthalmology and Visual Science (Abstracts) (42).
1. Comparative analysis of deeply phenotyped GBM cohorts of 'short-term' and 'long-term' survivors. Archita Biswas., Manuela Salvucci., Kate Connor., Jochen H M Prehn., GLIOTRAIN consortium. PMCID: PMC10322749, DOI: 10.1007/s11060-023-04341-3, Journal of Neurooncology.
2. Identification, validation and biological characterisation of novel glioblastoma tumour microenvironment subtypes: implications for precision immunotherapy. K White., M Meylan., A Bougoüin., F Bielle., A C O'Farrell., K Sweeney., L Weng., G Bergers., P Dicker., D M Ashley., E S Lipp., J T Low., J Zhao., P Wen., R Prins., M Verreault., A Idbaih., A Biswas., GLIOTRAIN consortium. Published: December06,2022DOI:https://doi.org/10.1016/j.annonc.2022.11.008, Annals of Oncology.
3. Ex vivo drug sensitivity screening predicts response to temozolomide in glioblastoma patients and identifies candidate biomarkers Ioannis Ntafoulis., Anne Kleijn., Jie Ju., Kevin Jimenez-Cowell., Federica Fabro., Michelle Klein., Romain Tching Chi Yen., Rutger K Balvers., Yunlei Li., Andrew P Stubbs., Trisha V Kers., Johan M Kros., Sean E Lawler., Laurens V Beerepoot., Andreas Kremer., Ahmed Idbaih., Maite Verreault., Annette T Byrne., Alice C O'Farrell., Kate Connor., Archita Biswas.,Manuela Salvucci., Jochen H M Prehn., Diether Lambrechts. Journal Neuro-Oncology. https://doi.org/10.1038/s41416-023-02402-y
4. Identification of inter- and intra-tumoral molecular phenotypes steering temozolomide resistance in patient-derived glioblastoma cells. Federica Fabro., Trisha V. Kers., Kate J. Feller., Cecile Beerens., Ioannis Ntafoulis., Ahmed Idbaih., Maite Verreault., Kate Conno.r, Archita Biswas., Manuela Salvucci., Jochen H.M. Prehn., Annette T. Byrne., Alice C. O’Farrell., Diether Lambrechts., Gonca Dilcan., Francesca Lodi., Ingrid Arijs., Andreas Kreme.r, Romain Tching Chi Yen., Miao-Ping Chien., Profile Martine L. M. Lamfers., Sieger Leenstra. International Journal of Molecular Sciences. https://doi.org/10.1101/2023.08.11.552418
1. Decarli, M. C., Amaral, R., Dos Santos, D. P., Tofani, L. B., Katayama, E., Rezende, R. A., ... & Moraes, A. M. (2021). Cell spheroids as a versatile research platform: formation mechanisms, high throughput production, characterization and applications. Biofabrication, 13(3), 032002. https://doi.org/10.1088/1758-5090/abe6f2
2. Gil, L. V. G., Singh, H., da Silva, J. D. S., dos Santos, D. P., Covas, D. T., Swiech, K., & Suazo, C. A. T. (2020). Feasibility of the taylor vortex flow bioreactor for mesenchymal stromal cell expansion on microcarriers. Biochemical Engineering Journal, 162, 107710. https://doi.org/10.1016/j.bej.2020.107710.2020.
3. Decarli, M. C., Dos Santos, D. P., Astray, R. M., Ventini-Monteiro, D. C., Jorge, S. A. C., Correia, D. M., ... & Suazo, C. A. T. (2018). Drosophila S2 cell culture in a WAVE Bioreactor: potential for scaling up the production of the recombinant rabies virus glycoprotein. Applied microbiology and biotechnology, 102, 4773-4783. https://doi.org/10.1007/s00253-018-8962-0.
1. Chain MO, Paiva CAM, Maciel IO, Neto AN, Castro VF, Oliveira CP, Mendonça BDS, Nestal de Moraes G, Reis SAD, Carvalho MA, De-Melo LDB. (2020) Galectin-3 mediates survival and apoptosis pathways during Trypanosoma cruzi-host cell interplay. Exp Parasitol.
1. Mousavi, S. E., Fard, M. Z., Rezayat, S. M., & Naraki, K. (2021). Investigation of the Effects of Zinc Oxide Nanoparticles on Membrane Damage of Human Neuroblastoma Cell Lineage (SH-SY5Y) and Change of Tau Protein Structure by SpectroscopicMethods.
2. Zivari Fard, M., Fatholahi, M., Abyadeh, M., Bakhtiarian, A., Mousavi, S. E., & Falahati, M. (2020). The Investigation of the Cytotoxicity of Copper Oxide Nanoparticles on Peripheral Blood Mononuclear Cells. Nanomedicine Research Journal, 5(4), 364-368.
3. Zivari Fard, M., Sharifi, M., Shojaei, A., Rezayat, S. M., Mousavi, S. E., & Falahati, M. (2021). The Investigation of the Toxicity of Palladium Nanoparticles on Human Lymphocyte. Journal of Nanoanalysis, 8(2), 151-157.

Publications

Sakis (Athanasios) MantalarisList of Publications

Research Article Papers

Review Papers

Book Chapters

Prof. Nicki Panoskaltsis List of Publications

Research Articles

Review Articles

Book Chapters

Rest of the TeamSelected Publications

Elizabeth Matthews, PhD

Archita Biswas, PhD

Diogo Peres Dos Santos, PhD

Michelle de Oliveira Chain, PhD

Maryam Zivari Fard, M.Sc

Sakis (Athanasios) Mantalaris
List of Publications

Prof. Nicki Panoskaltsis
List of Publications

Rest of the Team
Selected Publications